Skip to main content

Table 2 Estimation of the attenuation factor, c, required to compute the correlations, R is , between hazard ratios on the I-outcome and D-outcome.

From: Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

Acc rate

α 1, α 2 , α 3

Under H 1

Under H 0

    

R 13

c

R 23

c

R 13

c

R 23

c

250

0.5, 0.25, 0.025

0.526

0.728

0.361

0.69

0.493

0.68

0.367

0.70

0.504

0.69

 

0.2, 0.1, 0.025

0.776

0.907

0.529

0.68

0.594

0.66

0.529

0.68

0.598

0.66

500

0.5, 0.25, 0.025

0.527

0.728

0.369

0.70

0.476

0.64

0.383

0.73

0.487

0.67

 

0.2, 0.1, 0.025

0.778

0.909

0.505

0.65

0.575

0.63

0.512

0.66

0.577

0.63

  1. "Acc. rate" denotes the accrual rate of patients per unit time
Back to article page

Trials

ISSN: 1745-6215