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Table 10 Estimates of correlations R ij .

From: Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

R ij

i= 1

i= 2

i= 3

i= 4

j = 1

1

0.715

0.569

0.512

j = 2

0.722

1

0.793

0.717

j = 3

0.579

0.802

1

0.904

j = 4

0.529

0.733

0.914

1

  1. Lower triangle (in italics), based on equation (15); upper triangle, estimates based on simulation under Δ = 0.75, 5000 replications
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Trials

ISSN: 1745-6215