Table 5 Optic nerve-based measures in patients and controls
| Â | PATIENTS | CONTROLS | Â | |
|---|---|---|---|---|
| Â | Clinically Affected (mean, SD) | Clinically Unaffected (mean, SD) | (mean, SD) | p* |
Number of optic nerves (n) | 14 | 6 | 16 | - |
RNFL average thickness (microns) | 72.4 (12.9) | 85.5 (10.2) | 101.6 (12.1) | 0.0093 |
Macular volume (mm 3 ) | 6.1 (0.5) | 6.6 (0.3) | 6.9 (0.4) | 0.1211 |
Optic nerve area (mm 2 ) | 8.1 (1.3) | 8.9 (1.1) | 10.3 (0.8) | 0.0123 |
Optic nerve MTR (pu) | 28.4 (2.9) | 31.3 (2.3) | 32.9 (3.4) | 0.2700 |
Optic nerve DTI Mean Diffusivity (×10 -3 mm 2 /s) | 1.17 (0.29) | 1.25 (0.26) | 0.97 (0.13) | 0.0145 |
Optic nerve DTI Fractional Anisotropy (×10 3 ) | 298.2 (91.2) | 353.3 (88.6) | 530.6 (99.7) | 0.0004 |
Optic nerve DTI Radial Diffusivity (×10 -3 mm 2 /s) | 0.99 (0.26) | 1.03 (0.24) | 0.67 (0.13) | 0.0007 |
Optic nerve DTI Axial Diffusivity (×10 -3 mm 2 /s) | 1.53 (0.42) | 1.70 (0.35) | 1.58 (0.23) | 0.4809 |