Impact on mortality and cancer incidence rates of using random invitation from population registers for recruitment to trials

Table 1 Standardized Mortality Ratios (SMR) for overall mortality and by subgroup.

	Number	Expected Mortality	Observed Mortality	SMR	*L95%CI*	*U95%CI*
OVERALL	202593	12247	4569	37.3%	*36.2%*	*38.4%*
CENTRE
Gateshead	17321	1140	469	41.1%	37.5%	45.0%
St Barts London	19963	1199	474	39.5%	36.0%	43.2%
Liverpool	10108	613	297	48.4%	43.1%	54.3%
Nottingham	16765	1091	430	39.4%	35.8%	43.3%
Manchester	16498	940	375	39.9%	35.9%	44.1%
Derby	14917	858	312	36.4%	32.5%	40.7%
Royal Free London	16709	920	306	33.3%	29.7%	37.2%
Portsmouth	19175	1341	490	36.5%	33.4%	39.9%
Bristol	16556	1108	342	30.9%	27.7%	34.3%
Belfast	13579	750	241	32.2%	28.2%	36.5%
Cardiff	16756	886	338	38.2%	34.2%	42.5%
North Wales	14324	861	298	34.6%	30.8%	38.8%
Middleborough	9922	541	197	36.4%	31.5%	41.9%
AGE GROUP
50-54	39392	882	417	47.3%	42.8%	52.0%
55-59	55592	1977	825	41.7%	38.9%	44.7%
60-64	47073	2658	948	35.7%	33.4%	38.0%
65-69	38568	3530	1259	35.7%	33.7%	37.7%
70-74	21967	3200	1120	35.0%	33.0%	37.1%
BMI SCORE
Underweight (up to 18.5)	2548	157	111	70.6%	58.1%	85.0%
Normal (18.5-25)	82888	4903	1701	34.7%	33.1%	36.4%
Overweight (25-30)	74284	4640	1586	34.2%	32.5%	35.9%
Obese (over 30)	41903	2486	1113	44.8%	42.2%	47.5%
YEAR IN TRIAL	(women years)
1^st	202501	1732	320	18.5%	16.5%	20.6%
2^nd	202028	1914	660	34.5%	31.9%	37.2%
3^rd	201314	2111	800	37.9%	35.3%	40.6%
4^th	197029	2290	903	39.4%	36.9%	42.1%
5^th	156319	1955	841	43.0%	40.2%	46.0%
6^th	106119	1393	631	45.3%	41.8%	49.0%
7^th	49590	719	349	48.6%	43.6%	53.9%
8^th	8136	133	65	49.0%	37.9%	62.5%

ISSN: 1745-6215