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Table 1 Inclusion and exclusion criteria

From: Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial

Inclusion criteria
   • Male or female
   • 25 years of age or older
   • Three or more periodontal pockets with a probing depth (PD) > 5 mm
   • Have at least 16 natural teeth excluding third molars
   • Provide informed consent and willingness to cooperate with the study protocol
Exclusion Criteria
   • History of antibiotic use in the previous three months
   • Pregnant or lactating females
   • Treatment with antihypertensive, antilipemic, antiarrhythmic, and other cardiovascular drugs
   • Systemic diseases such as diabetes, HIV/AIDS, liver disease, chronic renal failure, tuberculosis, and autoimmune diseases
   • Previous history of cardiovascular disease: Acute myocardial infarct, stable angina, unstable angina, heart failure, atrial fibrillation, AV blockade, peripheral vascular disease, and cerebrovascular accident
   • Patients who received periodontal treatment within the last 6 months
   • Patients who require antibiotic prophylaxis before examination or treatment
   • Patients with some mental disability