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Table 6 Data collection at Clinic visits (Baseline and Week 8): Electrophysiological and Autonomic data

From: International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol

Domain Task Measure* Time (minutes) Method Administrator
Electrophysiological      
Resting condition Eyes Open Frontal Alpha Asymmetrya
Fronto-parietal Alpha powera
Fronto-parietal Theta powerb
2 EEG CTC
Activation tasks Oddball Fronto-Parietal P300 ERPa 6 ERP CTC
  Continuous Performance Test (CPT) Frontal P450 ERPa 8 ERP CTC
  Novelty Frontal Early P300 ERPa    
  Go-No Go Frontal N200 ERPa 6 ERP CTC
  Emotion (masked, nonconscious) Temporo-occipital P120, Fronto-central VPP ERPb 6 ERP CTC
  Emotion (unmasked, conscious) Temporo-occipital P120, Fronto-central VPP ERPb 6 ERP CTC
  Startle 'noise burst' Fronto-central N100-P200 ERPb 4 ERP CTC
Autonomic      
Resting condition Eyes Open Average Heart Ratea
Heart Rate Variabilitya
  ECG  
Activation tasks Startle Eye blinkb   EMG CTC
  Oddball, CPT, Novelty,
Go-NoGo,
Emotion (masked, unmasked)
Average Heart Rate, Heart Rate Variabilitya
Average Skin conductance levela
  ECG Electro-dermal activity  
  1. a Hypothesized contrast is Treatment Responders < Non-Responders
  2. b Hypothesized contrast is Treatment Responders > Non-Responders
  3. Abbreviations:
  4. Part. = Participant
  5. CTC = Clinical Trial Coordinator
  6. CPT = Continuous Performance Test
  7. EEG = Electroencephalogram,
  8. ERP = Event Related Potential,
  9. EMG = Electromyogram (Orbicularis Occuli)
  10. ECG = Electrocardiogram
  11. *These are representative measures based on previous findings; additional EEG measures from other recording sites may also be analyzed