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Table 6 Data collection at Clinic visits (Baseline and Week 8): Electrophysiological and Autonomic data

From: International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol

Domain

Task

Measure*

Time (minutes)

Method

Administrator

Electrophysiological

     

Resting condition

Eyes Open

Frontal Alpha Asymmetrya

Fronto-parietal Alpha powera

Fronto-parietal Theta powerb

2

EEG

CTC

Activation tasks

Oddball

Fronto-Parietal P300 ERPa

6

ERP

CTC

 

Continuous Performance Test (CPT)

Frontal P450 ERPa

8

ERP

CTC

 

Novelty

Frontal Early P300 ERPa

   
 

Go-No Go

Frontal N200 ERPa

6

ERP

CTC

 

Emotion (masked, nonconscious)

Temporo-occipital P120, Fronto-central VPP ERPb

6

ERP

CTC

 

Emotion (unmasked, conscious)

Temporo-occipital P120, Fronto-central VPP ERPb

6

ERP

CTC

 

Startle 'noise burst'

Fronto-central N100-P200 ERPb

4

ERP

CTC

Autonomic

     

Resting condition

Eyes Open

Average Heart Ratea

Heart Rate Variabilitya

 

ECG

 

Activation tasks

Startle

Eye blinkb

 

EMG

CTC

 

Oddball, CPT, Novelty,

Go-NoGo,

Emotion (masked, unmasked)

Average Heart Rate, Heart Rate Variabilitya

Average Skin conductance levela

 

ECG Electro-dermal activity

 
  1. a Hypothesized contrast is Treatment Responders < Non-Responders
  2. b Hypothesized contrast is Treatment Responders > Non-Responders
  3. Abbreviations:
  4. Part. = Participant
  5. CTC = Clinical Trial Coordinator
  6. CPT = Continuous Performance Test
  7. EEG = Electroencephalogram,
  8. ERP = Event Related Potential,
  9. EMG = Electromyogram (Orbicularis Occuli)
  10. ECG = Electrocardiogram
  11. *These are representative measures based on previous findings; additional EEG measures from other recording sites may also be analyzed