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Table 5 Data collection at Clinic visits (Baseline and Week 8): Cognitive data for 'Thinking' processes

From: International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol

Domain Sub-domain Task Measurea Time (minutes) Method Administrator
Thinking Response Speed Motor Tapping Number of Taps 30 Touchscreen Part.
    Variability of Pause between Taps    
  Impulsivity Go-NoGo Reaction Time 30 Touchscreen Part.
    Variability of Reaction Time    
    False 'alarm' errors    
  Attention-Concentration Continuous Performance Test Reaction Time 30 Touchscreen Part,
    False 'alarm' errors    
    False 'miss' errors    
  Information Processing Efficiency Switching of Attention Completion Time (digits + letters) 30 Touchscreen Part.
    Average Connection Time (digits + letters)    
    Errors (digits+letters)    
   Verbal Interference Part 2- Part 1 Errors 30 Touchscreen Part.
    Part 2- Part 1 Reaction Time    
   Choice Reaction Time Reaction Time 30 Touchscreen Part.
  Memory Digit Span Recall Span 30 Touchscreen Part.
    Trials correct    
   Memory Recognition Total immediate recall trials 1-4 30 Touchscreen Part.
    Learning rate trials 1-4    
    Delayed recall trial 7    
  Executive Function Maze Completion Time 30 Touchscreen Part.
    Path Learning Time    
    Overrun Errors    
    Total Errors    
  1. a Hypothesized contrast is Treatment Responders < Non-Responders
  2. (with a common direction of reduction for poorer accuracy, reduced variability, and slowed reaction time)
  3. Abbreviations:
  4. Part. = Participant