Table 4 Withdrawal criteria

Pregnancy

Hypophosphataemia (serum PO₄ <0.8 mmol/L despite dose reduction of treatment/placebo)

Hyperphosphataemia (serum PO₄ >1.8 mmol/L in subjects receiving placebo)

Occurrence of any serious adverse event, intercurrent illness or laboratory abnormality which, in the opinion of the investigators, warrants the subject's permanent withdrawal from the study

Poor compliance with study medication

Poor attendance at study visits

Subject inability to tolerate study medication due to side effect profile

Subject decision to withdraw

Deteriorating renal function

Subject lost to follow-up (loss of contact before final study visit)