Skip to main content

Table 2b Clinical characteristics at randomisation not used in minimisation algorithm, and recorded at randomisation

From: Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited

   No. (%)
Cardiac rhythm Sinus rhythm, not AF 2121 (70%)
  Atrial fibrillation 914 (30%)
Systolic BP at randomisation < = 140 mmHg 897 (30%)
  141 to 180 mmHg 1738 (57%)
  > 180 mmHg 400 (13%)
  median (interquartile range) 155 (140, 170)
Diastolic BP at randomisation < = 80 mmHg 1537 (51%)
  81 to 110 mmHg 1420 (47%)
  > 110 mmHg 78 (3%)
  median (interquartile range) 80 (71, 91)
Blood glucose1 < 3.5 mmol/l 7 (0%)
  3.5-6 mmol/l 532 (18%)
  6-8 mmol/l 1654 (54%)
  > 8 mmol/l 559 (18%)
  not measured (old form) 283 (9%)
  median (interquartile range) 7.0 (6.0, 8.0)
Probability of being alive and independent at 6 m2 < 0.30 1383 (46%)
  > = 0.30 1652 (54%)
  median (interquartile range) 0.35 (0.12, 0.59)
Recruited at a centre with pre-trial experience3 Centres without pre-trial experience 1891 (62%)
  Centre with pre-trial experience 1144 (38%)
Doctor's opinion of scan at randomisation Normal 1792 (59%)
  Possible evidence of recent ischaemic change 701 (23%)
  Definite evidence of recent ischaemic change 542 (18%)
  1. 1. For the first 282 patients, glucose was not recorded. After patient 282, it was collected at randomisation. Glucose therefore was not available for those 282 patients
  2. 2. Probability calculated with a validated prognostic model from baseline data [14].
  3. 3. Pre-trial experience of thrombolysis is defined as having had a protocol for open label rtPA and had treated at least 3 people in the 12 months before joining the trial; 76 (49%) centres met this criterion.