Subjects > 18 years of age
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Contraindication for use of ARB
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Either gender
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Urgent need for revascularization procedure
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First episode of acute MI
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Severe heart failure (NYHA IV or need for inotropic support)
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Typical pain lasting ≥ 20 minutes
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Persistent (>1 hour) severe hypotension (systolic blood pressure < 90 mmHg)
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ST elevation of more than 1 mm in at least 2 separate leads on the ECG
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Refractory or potentially lethal arrhythmias
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An echocardiographic LV EF < 50%
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Hemodynamically significant right ventricular infarction
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Optimal recording of echocardiographic imaging of apical chamber views
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Congenital heart disease
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Patients who provide written informed consent
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Primary valvular disease, severer than mild degree
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Idiopathic hypertrophic cardiomyopathy
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Concomitant inflammatory cardiomyopathy
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Significant renal dysfunction (serum creatinine 2.5 mg/dl)
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Significant hepatic dysfunction (serum transaminase more than 3 times normal)
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Anemia (hemoglobin < 10 mg/mL or 6 mmol/L)
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Psychiatric disorders, alcohol or drug abuse
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Life expectancy is less than 1 year
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Participation in any other pharmacological study within 2 months
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Refusal or inability to provide informal consent
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