Table 2 Timeline of participants' progression through the stage-two trial

Medical history

●

Physical examination

●

●

●

●

●

●

●

●

Joint function

●

●

●

●

●

●

●

●

Swollen joint count

●

●

●

●

●

●

●

●

Tender joint count

●

●

●

●

●

●

●

●

Physician global status

●

●

●

●

●

●

●

●

●

Patient global assessment

●

●

●

●

●

●

●

●

Morning stiffness

●

●

●

●

●

●

●

●

Pain at rest

●

●

●

●

●

●

●

●

Pattern based on CM

(symptoms)

●

●

●

●

●

●

●

●

●

Blood test

●

●

●

●

●

Routine urine test

●

●

●

●

●

Stool routine test

●

●

●

CRP

●

●

●

ESR

●

●

●

RF

●

●

●

ALT

●

●

●

●

●

AST

●

●

●

●

●

Bilirubin

●

●

●

Cr

●

●

●

●

●

BUN

●

●

●

●

●

VAS

●

●

●

●

●

●

●

HAQ

●

●

●

EGG

●

●

X-ray

●

●

Adverse events

●

●

●

●

●

●

●

●