Mean level ± SD at end of treatment period | Mean difference (95% CI) | P-values | |||||
---|---|---|---|---|---|---|---|
N | Placebo | Rostafuroxin | Rostafuroxin minus placebo | Treatment effect | Carryover effect | Period effect | |
Systolic pressure, mm Hg | |||||||
0.05 mg | 55 | 131.9 ± 10.7 | 133.9 ± 11.5 | 2.02 (-0.68 to 4.73) | 0.139 | 0.129 | 0.282 |
0.15 mg | 39 | 130.9 ± 10.7 | 131.5 ± 11.8 | 0.51 (-2.59 to 3.60) | 0.743 | 0.179 | 0.588 |
0.5 mg | 36 | 135.2 ± 9.5 | 135.2 ± 9.4 | 0.04 (-3.38 to 3.46) | 0.981 | 0.523 | 0.815 |
1.5 mg | 40 | 135.3 ± 14.0 | 137.7 ± 11.7 | 2.39 (-1.20 to 5.99) | 0.185 | 0.975 | 0.193 |
5.0 mg | 44 | 133.7 ± 10.5 | 133.0 ± 12.2 | -0.68 (-3.72 to 2.36) | 0.654 | 0.831 | 0.749 |
All doses | 214 | 133.3 ± 11.2 | 134.2 ± 11.5 | 0.91 (-0.45 to 2.28) | 0.188 | 0.598 | 0.911 |
Diastolic pressure, mm Hg | |||||||
0.05 mg | 55 | 80.4 ± 7.4 | 81.9 ± 7.8 | 1.53 (-0.22 to 3.28) | 0.085 | 0.238 | 0.436 |
0.15 mg | 39 | 81.9 ± 7.6 | 81.5 ± 8.1 | -0.42(-2.80 to 1.97) | 0.725 | 0.952 | 0.328 |
0.5 mg | 36 | 85.6 ± 7.8 | 84.2 ± 9.1 | -1.42(-3.77 to 0.94) | 0.230 | 0.803 | 0.739 |
1.5 mg | 40 | 82.5 ± 9.5 | 84.0 ± 7.7 | 1.52 (-0.42 to 3.47) | 0.121 | 0.667 | 0.463 |
5.0 mg | 44 | 82.4 ± 7.4 | 82.2 ± 6.9 | -0.16 (-2.07 to 1.75) | 0.867 | 0.719 | 0.927 |
All doses | 214 | 82.4 ± 8.0 | 82.7 ± 7.9 | 0.32 (-0.57 to 1.22) | 0.474 | 0.405 | 0.757 |