Mean level ± SD at end of treatment period | Mean difference (95% CI) | P-values | |||||
---|---|---|---|---|---|---|---|
N | Placebo | Rostafuroxin | Rostafuroxin minus placebo | Treatment effect | Carryover effect | Period effect | |
Systolic pressure, mm Hg | |||||||
0.05 mg | 57 | 141.1 ± 11.8 | 145.8 ± 12.8 | 4.59 (1.43 to 7.74) | 0.005 | 0.319 | 0.174 |
0.15 mg | 41 | 140.3 ± 12.1 | 140.7 ± 13.8 | 0.26 (-4.10 to 4.61) | 0.906 | 0.312 | 0.062 |
0.5 mg | 38 | 142.1 ± 15.5 | 142.9 ± 13.4 | 0.72 (-4.01 to 5.45) | 0.759 | 0.271 | 0.530 |
1.5 mg | 41 | 140.9 ± 11.8 | 142.9 ± 12.6 | 2.02 (-1.46 to 5.51) | 0.248 | 0.414 | 0.959 |
5.0 mg | 48 | 139.1 ± 9.9 | 142.1 ± 12.9 | 2.89 (-0.54 to 6.31) | 0.096 | 0.477 | 0.113 |
All doses | 225 | 140.7 ± 12.1 | 143.0 ± 13.1 | 2.35 (0.71 to 4.00) | 0.005 | 0.674 | 0.044 |
Diastolic pressure, mm Hg | |||||||
0.05 mg | 57 | 87.4 ± 8.4 | 89.2 ± 8.5 | 1.78 (-0.45 to 4.01) | 0.115 | 0.951 | 0.417 |
0.15 mg | 41 | 88.0 ± 8.5 | 88.3 ± 9.9 | 0.29 (-2.30 to 2.88) | 0.823 | 0.836 | 0.252 |
0.5 mg | 38 | 87.8 ± 8.6 | 88.6 ± 8.2 | 0.80 (-2.61 to 4.21) | 0.636 | 0.112 | 0.873 |
1.5 mg | 41 | 88.0 ± 8.9 | 90.8 ± 6.4 | 2.82 (0.51 to 5.12) | 0.018 | 0.344 | 0.191 |
5.0 mg | 48 | 86.7 ± 8.0 | 88.4 ± 7.8 | 1.74 (-1.17 to 4.66) | 0.235 | 0.510 | 0.173 |
All doses | 225 | 87.5 ± 8.4 | 89.1 ± 8.2 | 1.53 (0.37 to 2.69) | 0.010 | 0.714 | 0.033 |