Table 3 24-h ambulatory blood pressure on treatment with placebo and different daily doses of rostafuroxin
Mean level ± SD at end of treatment period | Mean difference (95% CI) | P-values | |||||
|---|---|---|---|---|---|---|---|
N | Placebo | Rostafuroxin | Rostafuroxin minus placebo | Treatment effect | Carryover effect | Period effect | |
Systolic pressure, mm Hg | |||||||
0.05 mg | 79 | 133.1 ± 10.8 | 134.1 ± 11.2 | 0.99 (-1.42 to 3.40) | 0.417 | 0.398 | 0.324 |
0.15 mg | 76 | 134.8 ± 13.3 | 134.7 ± 12.0 | -0.07 (-2.73 to 2.58) | 0.957 | 0.348 | 0.166 |
0.5 mg | 72 | 137.0 ± 10.7 | 137.0 ± 10.8 | 0.08 (-2.27 to 2.43) | 0.945 | 0.790 | 0.889 |
1.5 mg | 80 | 136.7 ± 13.1 | 137.8 ± 10.7 | 1.11 (-1.04 to 3.26) | 0.306 | 0.753 | 0.741 |
5.0 mg | 76 | 136.3 ± 11.8 | 135.9 ± 12.9 | -0.36 (-2.37 to 1.64) | 0.719 | 0.854 | 0.696 |
All doses | 383 | 135.6 ± 12.0 | 135.9 ± 11.6 | -0.36 (-0.67 to 1.38) | 0.493 | 0.926 | 0.860 |
Diastolic pressure, mm Hg | |||||||
0.05 mg | 79 | 82.5 ± 8.3 | 83.2 ± 8.3 | 0.75 (-0.92 to 2.41) | 0.374 | 0.611 | 0.446 |
0.15 mg | 76 | 83.4 ± 9.0 | 83.1 ± 9.3 | -0.29(-2.03 to 1.45) | 0.743 | 0.467 | 0.155 |
0.5 mg | 72 | 86.2 ± 8.4 | 85.2 ± 9.0 | -1.01(-2.59 to 0.58) | 0.210 | 0.459 | 0.630 |
1.5 mg | 80 | 84.9 ± 9.3 | 85.4 ± 7.7 | 0.56 (-0.66 to 1.77) | 0.365 | 0.900 | 0.559 |
5.0 mg | 76 | 84.7 ± 8.5 | 84.8 ± 8.6 | 0.18 (-1.11 to 1.46) | 0.785 | 0.687 | 0.677 |
All doses | 383 | 84.3 ± 8.8 | 84.3 ± 8.6 | 0.05 (-0.61 to 0.72) | 0.882 | 0.457 | 0.971 |