Table 2 Office blood pressure on treatment with placebo or different daily doses of rostafuroxin
Mean level ± SD at end of treatment period | Mean difference (95% CI) | P-values | |||||
|---|---|---|---|---|---|---|---|
N | Placebo | Rostafuroxin | Rostafuroxin minus placebo | Treatment effect | Carryover effect | Period effect | |
Systolic pressure, mm Hg | |||||||
0.05 mg | 83 | 142.0 ± 11.1 | 144.7 ± 12.2 | 2.72 (0.07 to 5.36) | 0.044 | 0.352 | 0.229 |
0.15 mg | 82 | 143.6 ± 13.5 | 143.3 ± 13.9 | -0.18(-3.21 to 2.85) | 0.905 | 0.897 | 0.364 |
0.5 mg | 77 | 145.3 ± 13.8 | 145.9 ± 13.3 | 0.49 (-2.38 to 3.36) | 0.732 | 0.326 | 0.770 |
1.5 mg | 86 | 145.8 ± 13.7 | 146.8 ± 15.1 | 1.11 (-1.32 to 3.54) | 0.366 | 0.828 | 0.723 |
5.0 mg | 82 | 142.1 ± 12.1 | 144.5 ± 14.3 | 2.29 (-0.35 to 4.93) | 0.089 | 0.667 | 0.038 |
All doses | 410 | 143.7 ± 12.9 | 145.1 ± 13.8 | 1.30 (0.10 to 2.50) | 0.034 | 0.963 | 0.028 |
Diastolic pressure, mm Hg | |||||||
0.05 mg | 83 | 88.1 ± 8.3 | 89.9 ± 9.2 | 1.76 (0.01 to 3.51) | 0.049 | 0.846 | 0.639 |
0.15 mg | 82 | 88.7 ± 9.1 | 88.5 ± 9.6 | -0.25 (-2.03 to 1.54) | 0.786 | 0.596 | 0.296 |
0.5 mg | 77 | 90.6 ± 8.8 | 90.6 ± 8.2 | 0.02 (-1.92 to 1.95) | 0.986 | 0.112 | 0.905 |
1.5 mg | 86 | 90.5 ± 9.5 | 91.5 ± 8.9 | 0.98 (-0.65 to 2.61) | 0.235 | 0.580 | 0.027 |
5.0 mg | 82 | 88.4 ± 8.1 | 89.4 ± 8.5 | 0.97 (-1.01 to 2.95) | 0.333 | 0.431 | 0.163 |
All doses | 410 | 89.3 ± 8.8 | 90.0 ± 8.9 | 0.70 (-0.09 to 1.50) | 0.084 | 0.364 | 0.018 |