Skip to main content

Table 2 Variables names and comments.

From: The International Stroke Trial database

Randomisation data
HOSPNUM Hospital number
RDELAY Delay between stroke and randomisation in hours
RCONSC Conscious state at randomisation (F - fully alert, D - drowsy, U - unconscious)
SEX M = male; F = female
AGE Age in years
RSLEEP Symptoms noted on waking (Y/N)
RATRIAL Atrial fibrillation (Y/N); not coded for pilot phase - 984 patients
RCT CT before randomisation (Y/N)
RVISINF Infarct visible on CT (Y/N)
RHEP24 Heparin within 24 hours prior to randomisation (Y/N)
RASP3 Aspirin within 3 days prior to randomisation (Y/N)
RSBP Systolic blood pressure at randomisation (mmHg)
RDEF1 Face deficit (Y/N/C=can't assess)
RDEF2 Arm/hand deficit (Y/N/C=can't assess)
RDEF3 Leg/foot deficit (Y/N/C=can't assess)
RDEF4 Dysphasia (Y/N/C=can't assess)
RDEF5 Hemianopia (Y/N/C=can't assess)
RDEF6 Visuospatial disorder (Y/N/C=can't assess)
RDEF7 Brainstem/cerebellar signs (Y/N/C=can't assess)
RDEF8 Other deficit (Y/N/C=can't assess)
STYPE Stroke subtype (TACS/PACS/POCS/LACS/OTH=other)
RDATE Year and month of randomisation (yyyy-mm)
HOURLOCAL Local time - hours (99-missing data) of randomisation
MINLOCAL Local time - minutes (99-missing data) of randomisation
DAYLOCAL Estimate of local day of week; 1 - Sunday, 2-Monday, 3-Tuesday, 4-Wednesday, 5-Thursday, 6-Friday, 7-Saturday
RXASP Trial aspirin allocated (Y/N)
RXHEP Trial heparin allocated (M/L/N). The terminology for the allocated dose of unfractioned heparin changed slightly from the pilot to the main study. Patients were allocated either 12500 units subcutaneously twice daily (coded as H in the pilot and M in the main trial), 5000 units twice daily (coded as L throughout) or to 'avoid heparin' (coded as N throughout).
Data collected on 14 day/discharge form about treatments given in hospital
DASP14 Aspirin given for 14 days or till death or discharge (Y/N/U=unknown)
DASPLT Discharged on long term aspirin (Y/N/U=unknown)
DLH14 Low dose heparin given for 14 days or till death/discharge (Y/N/U=unknown)
DMH14 Medium dose heparin given for 14 days or till death/discharge (Y/N/U=unknown)
DHH14 Medium dose heparin given for 14 days etc in pilot (combine with above; Y/N)
ONDRUG Estimate of time in days on trial treatment
DSCH Non trial subcutaneous heparin (Y/N/U=unknown)
DIVH Non trial intravenous heparin (Y/N/U=unknown)
DAP Non trial antiplatelet drug (Y/N/U=unknown)
DOAC Other anticoagulants (Y/N/U=unknown)
DGORM Glycerol or manitol (Y/N/U=unknown)
DSTER Steroids (Y/N/U=unknown)
DCAA Calcium antagonists (Y/N/U=unknown)
DHAEMD Haemodilution (Y/N/U=unknown)
DCAREND Carotid surgery (Y/N/U=unknown)
DTHROMB Thrombolysis (Y/N/U=unknown)
DMAJNCH Major non-cerebral haemorrhage (Y/N/U=unknown)
DMAJNCHD Date of above (days elapsed from randomisation)
DMAJNCHX Comment on above
DSIDE Other side effect (Y/N/U=unknown)
DSIDED Date of above (days elapsed from randomisation)
DSIDEX Comment on above
Final diagnosis of initial event
DDIAGISC Ischaemic stroke (Y/N/U=unknown)
DDIAGHA Haemorrhagic stroke (Y/N/U=unknown)
DDIAGUN Indeterminate stroke (Y/N/U=unknown)
DNOSTRK Not a stroke (Y/N/U=unknown)
DNOSTRKX Comment on above
Recurrent stroke within 14 days
DRSISC Ischaemic recurrent stroke (Y/N/U=unknown)
DRSISCD Date of above (days elapsed from randomisation)
DRSH Haemorrhagic stroke (Y/N/U=unknown)
DRSHD Date of above (days elapsed from randomisation)
DRSUNK Unknown type (Y/N/U=unknown)
DRSUNKD Date of above (days elapsed from randomisation)
Other events within 14 days
DPE Pulmonary embolism; (Y/N/U=unknown)
DPED Date of above (days elapsed from randomisation)
DALIVE Discharged alive from hospital (Y/N/U=unknown)
DALIVED Date of above (days elapsed from randomisation)
DPLACE Discharge destination (A-Home/B-Relatives home/C-Residential care/D-Nursing home/E-Other hospital departments/U-Unknown)
DDEAD Dead on discharge form (Y/N/U=unknown)
DDEADD Date of above (days elapsed from randomisation); NOTE: this death is not necessarily within 14 days of randomisation
DDEADC Cause of death (1-Initial stroke/2-Recurrent stroke (ischaemic or unknown)/3-Recurrent stroke (haemorrhagic)/4-Pneumonia/5-Coronary heart disease/6-Pulmonary embolism/7-Other vascular or unknown/8-Non-vascular/0-unknown)
DDEADX Comment on death
Data collected at 6 months
FDEAD Dead at six month follow-up (Y/N/U=unknown)
FLASTD Date of last contact (days elapsed from randomisation)
FDEADD Date of death (days elapsed from randomisation); NOTE: this death is not necessarily within 6 months of randomisation
FDEADC Cause of death (1-Initial stroke/2-Recurrent stroke (ischaemic or unknown)/3-Recurrent stroke (haemorrhagic)/4-Pneumonia/5-Coronary heart disease/6-Pulmonary embolism/7-Other vascular or unknown/8-Non-vascular/0-unknown)
FDEADX Comment on death
FRECOVER Fully recovered at 6 month follow-up (Y/N/U=unknown)
FDENNIS Dependent at 6 month follow-up (Y/N/U=unknown)
FPLACE Place of residance at 6 month follow-up (A-Home/B-Relatives home/C-Residential care/D-Nursing home/E-Other hospital departments/U-Unknown)
FAP On antiplatelet drugs at six month follow-up (Y/N/U=unknown)
FOAC On oral anticoagulants at six month follow-up (Y/N/U=unknown)
Other data and derived variables
FU1_RECD Date discharge form received (days elapsed from randomisation)
FU2_DONE Date 6 month follow-up done (days elapsed from randomisation)
COUNTRY Abbreviated country code
CNTRYNUM Country code (see Table 1)
FU1_COMP Date discharge form completed (days elapsed from randomisation)
NCCODE Coding of compliance (see Table 3)
CMPLASP Compliant for aspirin (N/Y)
CMPLHEP Compliant for heparin (N/Y)
ID Indicator variable for death (1 = died; 0 = did not die)
TD Time of death or censoring in days
EXPDD Predicted probability of death/dependence at 6 month
EXPD6 Predicted probability of death at 6 month
EXPD14 Predicted probability of death at 14 days
SET14D Know to be dead or alive at 14 days (1 = Yes, 0 = No); this does not necessarily mean that we know outcome at 6 months - see OCCODE for this
ID14 Indicator of death at 14 days (1 = Yes, 0 = No)
OCCODE Six month outcome (1-dead/2-dependent/3-not recovered/4-recovered/0 or 9 - missing status
Indicator variables for specific causes of death
DEAD1 Initial stroke (1 = Yes, 0 = No)
DEAD2 Reccurent ischaemic/unknown stroke (1 = Yes, 0 = No)
DEAD3 Reccurent haemorrhagic stroke (1 = Yes, 0 = No)
DEAD4 Pneumonia (1 = Yes, 0 = No)
DEAD5 Coronary heart disease (1 = Yes, 0 = No)
DEAD6 Pulmonary embolism (1 = Yes, 0 = No)
DEAD7 Other vascular or unknown (1 = Yes, 0 = No)
DEAD8 Non vascular (1 = Yes, 0 = No)
H14 Cerebral bleed/heamorrhagic stroke within 14 days; this is slightly wider definition than DRSH and is used for analysis of cerebral bleeds; (1 = Yes, 0 = No)
ISC14 Indicator of ischaemic stroke within 14 days (1 = Yes, 0 = No)
NK14 Indicator of indeterminate stroke within 14 days (1 = Yes, 0 = No)
STRK14 Indicator of any stroke within 14 days (1 = Yes, 0 = No)
HTI14 Indicator of haemorrhagic transformation within 14 days (1 = Yes, 0 = No)
PE14 Indicator of pulmonary embolism within 14 days (1 = Yes, 0 = No)
DVT14 Indicator of deep vein thrombosis on discharge form (1 = Yes, 0 = No)
TRAN14 Indicator of major non-cerebral bleed within 14 days (1 = Yes, 0 = No)
NCB14 Indicator of any non-cerebral bleed within 14 days (1 = Yes, 0 = No)