Inclusion criteria |
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   1. Male or female over 20 years of age |
   2. Clinical indication for coronary angiography |
   3. Presence of at least one significant coronary artery stenosis (>50%) requiring PCI with stent implantation and one intermediate lesion with luminal narrowing of ≥30% and <70% by visual estimation on native coronary arteries. |
   4. Presence of at least one PCI target lesion (reference diameter 2.5~4 mm, lesion length ≤26 mm) with >50% diameter stenosis that can be covered with a single Zotrolimus-eluting stent (Endeavor Sprint, Medtronic Vascular Inc, Santa Rosa, CA). |
   5. Able to understand and willing to provide written informed consent |
Exclusion criteria |
   1. Intermediate lesions that might provide difficulty for IVUS evaluation because of following reasons: heavy calcification (>90° Arc), tortuous vessel with severe angulation, total occlusion, or bifurcation lesions |
   2. Previous PCI in the last 6 months |
   3. Previous coronary artery bypass graft |
   4. Patients with AMI undergoing primary PCI or rescue PCI after thrombolysis |
   5. Cardiogenic shock |
   6. Inability to take adequate antiplatelet therapy (aspirin and clopidogrel) |
   7. Thrombocytopenia (platelet count <70 × 109/l) |
   8. Known hypersensitivity or contraindication to any of the following medications: Heparin, aspirin, clopidogrel, cilostazol, probucol, statin, contrast media |
   9. History of severe ventricular arrhythmia |
   10. Significant QTc prolongation (≥470 ms) on electrocardiogram |
   11. Heart failure (New York Heart Association class III/IV) or left ventricular ejection fraction ≤35% |
   12. Familial hypercholesterolemia |
   13. Uncontrolled hypertriglyceridemia (>400 mg/dL) |
   14. Chronic renal failure with serum creatinine level ≥2 mg/dL |
   15. Severe liver disease or transaminase level ≥3 times the upper limit of normal. |
   16. Pregnancy or women at age of childbearing potential |