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Table 6 Presenting results showing heterogeneity in treatment effect (HTE)*

From: Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal

 

Weighted

Event Rate

Relative Risk Reduction

Number Needed to Treat

Predicted Risk*

Control

Intervention

(95% CI)

 

< 5%

15/428 (3.5%)

17/431 (3.9%)

-13% (-122%, 43%))**

-250**

5%-15%

66/581 (11.4%)

48/580 (8.3%)

27% (-4%, 49%)

32

> 15%

66/310 (21.3%)

38/307 (12.4%)

42% (16%, 60%)

11

Overall

147/1319 (11.1%)

103/1318 (7.8%)

30% (11%, 45%)

30

  1. * Although the predicted baseline risk can be shown in categories, the statistical testing of HTE should usually be based upon the full continuous variable. If standard predicted risk categories have been previously proposed in the validated prediction model, this should be stated, referenced appropriately, and clarified why these risk categories make sense (e.g. thresholds for deciding on whether some standard treatment is indicated, uncertain, or not indicated).
  2. ** Negative sign denotes net harm, denoting relative risk increase or number need to harm.
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