|
Aged 18 years and over
|
At any time
|
|
And Antidepressant therapy
|
Within last 3 months
|
|
And Diagnosis of moderate to severe depression
|
At any time
|
|
Patients excluded on basis of any one of
| |
|
Folate deficient <2.5 ng/L
|
At any time
|
|
B12 deficient <150 pg/ml
|
At any time
|
|
Taking folic acid supplements
|
Within last two months
|
|
Past diagnosis of psychosis
|
At any time
|
|
Pregnant or planning pregnancy
|
Within last 10 months
|
|
Taking anticonvulsants
|
At any time
|
|
Life expectancy less than 1 year
|
At any time
|
|
Any unstable medical condition
|
Within last 12 months
|
|
Taking Lithium
|
At any time
|
|
Any malignancy
|
At any time
|
|
Adverse reaction to folic acid
|
At any time
|
|
Depression resolved
|
Within last three months
|
|
Delirium
|
At any time
|
|
Learning disability
|
At any time
|
