Inclusion criteria | Time Frame |
---|---|
Aged 18 years and over | At any time |
And Antidepressant therapy | Within last 3 months |
And Diagnosis of moderate to severe depression | At any time |
Patients excluded on basis of any one of | Â |
Folate deficient <2.5 ng/L | At any time |
B12 deficient <150 pg/ml | At any time |
Taking folic acid supplements | Within last two months |
Past diagnosis of psychosis | At any time |
Pregnant or planning pregnancy | Within last 10 months |
Taking anticonvulsants | At any time |
Life expectancy less than 1 year | At any time |
Any unstable medical condition | Within last 12 months |
Taking Lithium | At any time |
Any malignancy | At any time |
Adverse reaction to folic acid | At any time |
Depression resolved | Within last three months |
Delirium | At any time |
Learning disability | At any time |