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Table 3 Trial inclusion and exclusion criteria used to search patient database

From: The Health Informatics Trial Enhancement Project (HITE): Using routinely collected primary care data to identify potential participants for a depression trial

Inclusion criteria

Time Frame

Aged 18 years and over

At any time

And Antidepressant therapy

Within last 3 months

And Diagnosis of moderate to severe depression

At any time

Patients excluded on basis of any one of

 

Folate deficient <2.5 ng/L

At any time

B12 deficient <150 pg/ml

At any time

Taking folic acid supplements

Within last two months

Past diagnosis of psychosis

At any time

Pregnant or planning pregnancy

Within last 10 months

Taking anticonvulsants

At any time

Life expectancy less than 1 year

At any time

Any unstable medical condition

Within last 12 months

Taking Lithium

At any time

Any malignancy

At any time

Adverse reaction to folic acid

At any time

Depression resolved

Within last three months

Delirium

At any time

Learning disability

At any time