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Table 1 Sample Size Calculation

From: Physical activity as a treatment for depression: the TREAD randomised trial protocol

total N randomised

N for primary analysis

power for 60% vs. 73% (OR = 1.80) 1

power for 20% vs. 33% (OR = 1.97) 2

detectable difference with 80% power 3

power to detect 3 BDI point difference

360

306

63%

69%

15%

82%

  1. 1 based on original sample size
  2. 2 revised calculation based on data from the IPCRESS study [24]
  3. 3 percentage difference of intervention group from usual care group assuming 20% recovery in usual care group