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Table 1 Stent Platform Comparison

From: A prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: Design and statistical methods of the PERSEUS clinical program

Component/Characteristic TAXUS Express TAXUS Liberté TAXUS Element Impact of Change
Stent Material 316L Stainless Steel 316L Stainless Steel Platinum Chromium Alloy Higher strength & radiopacity
Drug Paclitaxel N/A
Polymer Slow-Release Translute polymer N/A
Strut Width 71 μm-91 μm 76 μm-94 μm 61 μm-89 μm Greater flexibility, Lower profile, Reduced inflammation
Strut Thickness* 132 μm 97 μm 81 μm-86 μm  
Nominal Balloon Pressure 9 atm 9 atm for ≤2.50 mm 11 atm Optimized for stent/balloon configuration
   8 atm ≥2.75 mm   
Balloon Rated Burst Pressure 18 atm (2.25-4.0 mm)
16 atm (4.5-5.0 mm)
18 atm (2.0-4.0 mm)
16 atm (4.5-5.0 mm)
18 atm (2.0-2.25 mm)
16 atm (2.5-5.0 mm)
 
Surface-to-Artery Ratio 2.25mm: 20.0% 2.25 mm: 18.6% 2.25 mm: 17.8% More uniform drug delivery across stent diameters
  2.50 mm: 18.9% 2.50 mm: 17.6% 2.50 mm: 17.6%  
  3.00 mm: 15.2% 3.00 mm: 19.5% 3.00 mm: 16.4%  
  4.00 mm: 14.6% 4.00 mm: 17.1% 4.00 mm: 15.2%  
  1. * Strut thickness is 86 μm for the 4.00 mm model, and 81 μm for all other models.
  2. † Surface-to-Artery Ratio (SAR) is the percentage of artery wall area covered by outer surface area of the stent. Large values imply a greater surface area of drug coating in direct contact with the vessel and by inference, a larger dose delivered to the local arterial tissue. SAR can vary significantly by diameter for the same stent model. Increasing the number of stent models covering a diameter range decreases the variation of SAR by minimizing the stent's working range.
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