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Table 1 Stent Platform Comparison

From: A prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: Design and statistical methods of the PERSEUS clinical program

Component/Characteristic

TAXUS Express

TAXUS Liberté

TAXUS Element

Impact of Change

Stent Material

316L Stainless Steel

316L Stainless Steel

Platinum Chromium Alloy

Higher strength & radiopacity

Drug

Paclitaxel

N/A

Polymer

Slow-Release Translute polymer

N/A

Strut Width

71 μm-91 μm

76 μm-94 μm

61 μm-89 μm

Greater flexibility, Lower profile, Reduced inflammation

Strut Thickness*

132 μm

97 μm

81 μm-86 μm

 

Nominal Balloon Pressure

9 atm

9 atm for ≤2.50 mm

11 atm

Optimized for stent/balloon configuration

  

8 atm ≥2.75 mm

  

Balloon Rated Burst Pressure

18 atm (2.25-4.0 mm)

16 atm (4.5-5.0 mm)

18 atm (2.0-4.0 mm)

16 atm (4.5-5.0 mm)

18 atm (2.0-2.25 mm)

16 atm (2.5-5.0 mm)

 

Surface-to-Artery Ratio†

2.25mm: 20.0%

2.25 mm: 18.6%

2.25 mm: 17.8%

More uniform drug delivery across stent diameters

 

2.50 mm: 18.9%

2.50 mm: 17.6%

2.50 mm: 17.6%

 
 

3.00 mm: 15.2%

3.00 mm: 19.5%

3.00 mm: 16.4%

 
 

4.00 mm: 14.6%

4.00 mm: 17.1%

4.00 mm: 15.2%

 
  1. * Strut thickness is 86 μm for the 4.00 mm model, and 81 μm for all other models.
  2. † Surface-to-Artery Ratio (SAR) is the percentage of artery wall area covered by outer surface area of the stent. Large values imply a greater surface area of drug coating in direct contact with the vessel and by inference, a larger dose delivered to the local arterial tissue. SAR can vary significantly by diameter for the same stent model. Increasing the number of stent models covering a diameter range decreases the variation of SAR by minimizing the stent's working range.
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Trials

ISSN: 1745-6215