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Figure 4 | Trials

Figure 4

From: A prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: Design and statistical methods of the PERSEUS clinical program

Figure 4

Fibrin deposition around stent struts following TAXUS stent implantation in porcine coronary arteries. Swine coronary arteries were implanted with overlapping bare metal or TAXUS Express, TAXUS Liberté, or TAXUS Element paclitaxel-eluting stents and examined at 30, 90, and 180 days using light microscopy. Peristrut fibrin deposition was evaluated by study pathologists and scored on a 0-3 scale where 0 = no visible fibrin, 1 = mild fibrin present, 2 = moderate fibrin present, 3 = extensive fibrin present. Trichrome stained sections, 200× plate magnification. See Seifert et al., 2007 for more detailed methods [29]. (A) Example specimens at 180 days showing peristrut fibrin deposition histology. Number of specimens in each category is shown as n/N. (B) Number of specimens with extensive fibrin deposition (score 3) at each timepoint. There were no significant differences among control bare metal stents in any of the studies.

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