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Table 7 Antifungal agents for the prevention of mortality among patients with invasive candidemia (Perri D, O'Regan C, Cooper C, Nachega JB, Wu P, Tleyjeh I, Philips P, Mills EJ: Antifungal treatment for systemtic candida infectons: A mixed treatment comparison meta-analysis. Unpublished)

From: Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison

Treatment Comparison

Mixed Treatment Comparison

Adjusted Indirect Comparison

 

Odds Ratio

95% Credible Interval

Odds Ratio

95% Confidence Interval

Caspofungin vs. Fluconazole

1.01

(0.60, 1.71)

0.85

(0.44, 1.64)**

Amphotericin B Deoxycholate vs. Fluconazole

1.26

(0.96, 1.65)

1.31

(0.99, 1.74)

Amphotericin B Liposomal vs. Fluconazole

1.20

(0.70, 2.06)

-

-

Voriconazole vs. Fluconazole

1.20

(0.75, 1.94)

0.58

(0.33, 0.99)*, ***

Micafungin vs. Fluconazole

1.22

(0.68, 2.16)

-

-

Anidulafungin vs. Fluconazole

0.64

(0.36, 1.14)

0.65

(0.35, 1.19)

Itraconazole vs. Fluconazole

0.89

(0.46, 1.69

0.54

(0.27, 1.05)

Amphotericin B Deoxycholate vs. Caspofungin

1.24

(0.79, 1.94)

1.12

(0.62, 1.12)

Amphotericin B Liposomal vs. Caspofungin

1.19

(0.90, 1.57)

1.31

(0.90, 1.91)

Voriconazole vs. Caspofungin

1.19

(0.75, 1.89)

0.67

(0.32, 1.43)**

Micafungin vs. Caspofungin

1.20

(0.89, 1.62)

1.25

(0.84, 1.88)

Anidulafungin vs. Caspofungin

0.64

(0.29, 1.38)

-

-

Itraconazole vs. Caspofungin

0.87

(0.41, 1.84

0.63

(0.27, 1.47)

Amphotericin B Liposomal vs. Amphotericin B Deoxycholate

0.96

(0.60, 1.53)

1.80

(0.86, 3.76)**

Voriconazole vs. Amphotericin B Deoxycholate

0.96

(0.65, 1.42)

0.76

(0.48, 1.22)

Micafungin vs. Amphotericin B Deoxycholate

0.97

(0.58, 1.61)

0.95

(0.55, 1.64)

Anidulafungin vs. Amphotericin B Deoxycholate

0.51

(0.27, 0.96)

0.49

(0.25, 0.97)

Itraconazole vs. Amphotericin B Deoxycholate

0.70

(0.39, 1.27)

0.71

(0.39, 1.28)

Voriconazole vs. Amphotericin B Liposomal

1.00

(0.64, 1.55)

1.37

(0.77, 2.45)

Micafungin vs. Amphotericin B Liposomal

1.01

(0.75, 1.35)

0.96

(0.66, 1.40)

Anidulafungin vs. Amphotericin B Liposomal

0.54

(0.24, 1.17)

-

-

Itraconazole vs. Amphotericin B Liposomal

0.74

(0.34, 1.57)

-

-

Micafungin vs. Voriconazole

1.01

(0.61, 1.67)

-

-

Anidulafungin vs. Voriconazole

0.54

(0.25, 1.13)

-

-

Itraconazole vs. Voriconazole

0.74

(0.36, 1.50)

0.93

(0.43, 1.98)

Anidulafungin vs. Micafungin

0.53

(0.24, 1.19)

-

-

Itraconazole vs. Micafungin

0.73

(0.33, 1.59)

-

-

Itraconazole vs. Anidulafungin

1.37

(0.58, 3.26)

-

-

  1. Bolded text denotes head-to-head meta-analysis evaluations. * Mixed treatment method identifies a significant effect, adjusted indirect comparison does not, adjusted indirect comparison identifies significant effect, mixed treatment comparison does not. ** Direction of effect differs between approaches, ***Important effect size differences.
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