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Table 4 Topical treatment for treatment of ear discharge at 1 and 2 weeks[21].

From: Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison

Treatment Comparison

Mixed Treatment Comparison

Adjusted Indirect Comparison

 

Odds Ratio

95% Credible Interval

Odds Ratio

95% Confidence Interval

Topical Quinolone Antibiotic vs. No Treatment

0.13

(0.06, 0.24)

0.08

(0.01, 0.51)

Topical Non-Quinolone Antibiotic vs. No Treatment

0.21

(0.10, 0.44)

0.28

(0.09, 0.52)

Topical Antiseptic vs. No Treatment

0.71

(0.32, 1.55)

0.61

(0.22, 1.22)

Topical Non-Quinolone Antibiotic vs. Topical Quinolone Antibiotic

1.67

(1.17, 2.31)

1.62

(0.92, 2.85)

Topical Antiseptic vs. Topical Quinolone Antibiotic

5.64

(3.70, 8.70)

4.31

(1.34, 13.90)

Topical Antiseptic vs. Topical Non-Quinolone Antibiotic

3.37

(2.25, 5.03)

3.02

(0.74, 12.29)*

  1. Bolded text denotes head-to-head meta-analysis evaluations. * Mixed treatment method identifies a significant effect, adjusted indirect comparison does not, adjusted indirect comparison identifies significant effect, mixed treatment comparison does not. ** Direction of effect differs between approaches, ***Important effect size differences.
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Trials

ISSN: 1745-6215