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Figure 2 | Trials

Figure 2

From: A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning

Figure 2

Time course of (A) systolic, (B) diastolic and (C) mean arterial pressure (MAP) changes in placebo group (n = 12), level 1 (n = 12), level 2 (n = 12) and level 3 (n = 11) treatment groups in 24 hours. Note that in five patients at level 3, the clonidine was stopped at some stage because of hypotension (BP <80/40 mmHg) and patients were given extra fluids. Two-way ANOVA showed significant differences between clonidine doses in diastolic blood pressure (effect of treatment: F = 5.40, df = 3, P < 0.05; time post randomization: F = 1.31, df = 15, P > 0.05) and mean arterial pressure (effect of treatment: F = 5.62, df = 3, P < 0.05; time post randomization: F = 1.01, df = 15, P > 0.05) but not in the systolic blood pressure (effect of treatment: F = 2.46, df = 3, P > 0.05; time post randomization: F = 1.02, df = 15, P > 0.05). The Bonferroni post-test was also significant at the asterixed data points vs placebo (P < 0.05).

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