Figure 2From: A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning Time course of (A) systolic, (B) diastolic and (C) mean arterial pressure (MAP) changes in placebo group (n = 12), level 1 (n = 12), level 2 (n = 12) and level 3 (n = 11) treatment groups in 24 hours. Note that in five patients at level 3, the clonidine was stopped at some stage because of hypotension (BP <80/40 mmHg) and patients were given extra fluids. Two-way ANOVA showed significant differences between clonidine doses in diastolic blood pressure (effect of treatment: F = 5.40, df = 3, P < 0.05; time post randomization: F = 1.31, df = 15, P > 0.05) and mean arterial pressure (effect of treatment: F = 5.62, df = 3, P < 0.05; time post randomization: F = 1.01, df = 15, P > 0.05) but not in the systolic blood pressure (effect of treatment: F = 2.46, df = 3, P > 0.05; time post randomization: F = 1.02, df = 15, P > 0.05). The Bonferroni post-test was also significant at the asterixed data points vs placebo (P < 0.05).Back to article page