| NAC group(n = 45) | Placebo group(n = 45) | P value |
---|---|---|---|
Baseline clinical characteristics | Â | Â | Â |
   Age, years | 63.25 ± 9.78 | 65.09 ± 9.40 | 0.45 |
   Sex (male/female) | 20/25 | 34/11 | 0.005 |
   Body mass index, kg/m2 | 28.56 ± 4.81 | 27.85 ± 4.13 | 0.45 |
   Time since diagnosis of DM, years | 10.11 ± 8.50 | 9.82 ± 7.57 | 0.86 |
   Systolic blood pressure, mmHg | 156.05 ± 19.9 | 151.95 ± 18.4 | 0.34 |
   Diastolic blood pressure, mmHg | 82.63 ± 7.60 | 81.22 ± 7.14 | 0.39 |
   Ejection fraction, % | 49.45 ± 10.99 | 46.83 ± 14.15 | 0.37 |
Medications | Â | Â | Â |
   Aspirin, n(%) | 37(82.2%) | 36(80%) | 1.00 |
   ACE-inhibitors/ARB, n(%) | 32(71.1%) | 30(66.7%) | 0.82 |
   β-blockers, n(%) | 29(64.4%) | 35(77.8%) | 0.24 |
   Nitrates, n(%) | 30(66.7%) | 30(66.7%) | 1.00 |
   Diuretics, n(%) | 23(51.1%) | 19(42.2%) | 0.52 |
   Statins, n(%) | 28(62.2%) | 17(37.8%) | 0.034 |
   Digitals, n(%) | 6(13.3%) | 6(13.3%) | 1.00 |
Baseline laboratory values | Â | Â | Â |
   Serum creatinine, mg/dL | 1.736 ± 0.42 | 1.736 ± 0.17 | 1.00 |
   Serum urea nitrogen, mg/dL | 60.56 ± 28.37 | 58.64 ± 28.94 | 0.75 |
   Creatinine clearance, mL/min | 42.76 ± 11.97 | 43.97 ± 11.91 | 0.63 |