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Table 1 Baseline clinical, pharmacological, and laboratory characteristics of study patientsa
| NAC group(n = 45) | Placebo group(n = 45) | P value | |
|---|---|---|---|
| Baseline clinical characteristics | |||
| Age, years | 63.25 ± 9.78 | 65.09 ± 9.40 | 0.45 |
| Sex (male/female) | 20/25 | 34/11 | 0.005 |
| Body mass index, kg/m2 | 28.56 ± 4.81 | 27.85 ± 4.13 | 0.45 |
| Time since diagnosis of DM, years | 10.11 ± 8.50 | 9.82 ± 7.57 | 0.86 |
| Systolic blood pressure, mmHg | 156.05 ± 19.9 | 151.95 ± 18.4 | 0.34 |
| Diastolic blood pressure, mmHg | 82.63 ± 7.60 | 81.22 ± 7.14 | 0.39 |
| Ejection fraction, % | 49.45 ± 10.99 | 46.83 ± 14.15 | 0.37 |
| Medications | |||
| Aspirin, n(%) | 37(82.2%) | 36(80%) | 1.00 |
| ACE-inhibitors/ARB, n(%) | 32(71.1%) | 30(66.7%) | 0.82 |
| β-blockers, n(%) | 29(64.4%) | 35(77.8%) | 0.24 |
| Nitrates, n(%) | 30(66.7%) | 30(66.7%) | 1.00 |
| Diuretics, n(%) | 23(51.1%) | 19(42.2%) | 0.52 |
| Statins, n(%) | 28(62.2%) | 17(37.8%) | 0.034 |
| Digitals, n(%) | 6(13.3%) | 6(13.3%) | 1.00 |
| Baseline laboratory values | |||
| Serum creatinine, mg/dL | 1.736 ± 0.42 | 1.736 ± 0.17 | 1.00 |
| Serum urea nitrogen, mg/dL | 60.56 ± 28.37 | 58.64 ± 28.94 | 0.75 |
| Creatinine clearance, mL/min | 42.76 ± 11.97 | 43.97 ± 11.91 | 0.63 |
