From: Dealing with heterogeneity of treatment effects: is the literature up to the challenge?
Characteristic | Articles Represented | # RCTs Included |
---|---|---|
Journal of publication | ||
Annals | 30 (10) | 30 (9) |
BMJ | 43 (14) | 47 (15) |
JAMA | 45 (15) | 50 (16) |
Lancet | 97 (32) | 101 (32) |
NEJM | 88 (29) | 91 (29) |
Year of publication | ||
1994 | 86 (28) | 91 (29) |
1999 | 102 (34) | 106 (33) |
2004 | 115 (38) | 122 (38) |
Medical condition under study | ||
Cardiovascular | 69 (23) | 74 (23) |
Infectious Disease | 62 (20) | 70 (22) |
Cancer | 41 (14) | 42 (13) |
Psychiatry/Neurology | 25 (8) | 25 (8) |
Other | 106 (35) | 108 (34) |
First author's study region | ||
North America | 115 (38) | 121 (38) |
Other | 188 (62) | 198 (62) |
Study design | ||
Parallel | - | 304 (95) |
Crossover | - | 15 (5) |
Analysis reported | ||
HTE analysis | - | 92 (29) |
Subgroup without statistical comparison | - | 88 (28) |
None | - | 139 (44) |
Sample size | 262 (101 – 708) | |
- | [6–41,000] |