Example output from -nstage- for the reference scenario. This figure shows the exact output from using -nstage-. This does not include the Pilot stage for safety, concentrating only the particular issues relating to the application of the MAMS activity and efficacy stages. In this example, the durations are expressed in quarter-years. The variable factors have been chosen such that no arms are stopped early for lack-of-efficacy (there is 1 control arm and 5 research arms in each stage); the accrual rate is set at 500 patients/year; the median progression-free survival (PFS) and overall survival are estimated to be 24 months and 48 months, respectively; and accrual is uncapped ie recruitment continues to the point of overall maturity. The power was set at 95% for the three activity stages and the observed values are consistent with this.