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Table 6 Re-analysis over two stages of trials with final result showing no evidence of a difference employing PFS as an intermediate outcome.

From: How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

 

ICON3

one-sided sig.

e I

%

ρ

mean time

level at stage 1

 

err.

 

saved (yrs)

0.5

116

43.40

0.27

2.33

0.4

152

46.40

0.32

2.17

0.3

194

65.64

0.35

2.02

0.2

250

87.28

0.39

1.86

0.1

339

69.02

0.47

1.53

  1. For details see legend of table 5
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Trials

ISSN: 1745-6215