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Table 6 Re-analysis over two stages of trials with final result showing no evidence of a difference employing PFS as an intermediate outcome.

From: How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

  ICON3
one-sided sig. e I % ρ mean time
level at stage 1   err.   saved (yrs)
0.5 116 43.40 0.27 2.33
0.4 152 46.40 0.32 2.17
0.3 194 65.64 0.35 2.02
0.2 250 87.28 0.39 1.86
0.1 339 69.02 0.47 1.53
  1. For details see legend of table 5
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