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Table 4 Re-analysis of original trial data in trials showing no evidence of an effect on the final outcome.

From: How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

  ICON3 FOCUS
one-sided significance      A vs B A vs D A vs E A vs B A vs D A vs E
level at stage 1 δ I HR decision δ I HR    decision   
0.5 1 1.054 1 0.876 0.841 1.008
0.4 0.964 0.965 0.961 0.918 0.860 0.988
0.3 0.936 0.825 0.930 0.892 0.750 0.902
0.2 0.911 0.806 0.902 0.796 0.766 0.946
0.1 0.885 0.837 0.874 0.887 0.879 0.937
  1. δ I gives the cut-off hazard ratio for the intermediate outcome at a given one-sided significance level, HR gives the observed hazard ratio at that point in time, denotes that the trial would have been correctly stopped at that stage, ✗ denotes that the trial would have been incorrectly carried on to the next stage
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