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Table 2 Parameter values for trial re-analysis based on trial protocols

From: How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

Parameter ICON3 ICON4 RE01 FOCUS
Number of arms 2 2 2 5
Targeted hazard ratio intermediate outcome 0.75 0.75 0.71 0.73
Targeted hazard ratio final outcome 0.75 0.74 0.71 0.73
Power at 1st stage 95% 95% 95% 95%
Power at 2nd stage 90% 90% 90% 90%
Overall power (given by nstage.ado program) 87.4% 87.4% 87.4% 87.4%
Significance level at 2nd stage (one-sided) 2.5% 2.5% 2.5% 0.5%
Overall significance level (for stage 1 α = 0.1) 1.39% 1.39% 1.39% 0.35%
Allocation ratio (control:experimental) 2:1 1:1 1:1 2:1:1:1:1
Intermediate outcome (median survival) 1.5 years 10 months 2.5 months 9 months
Final outcome (median survival) 3 years 23 months 10 months 9 months
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