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Table 2 Criteria for judging the strength of a subgroup claim

From: Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials

Criteria

Strong claim

Claim of a likely effect

Suggestion of a possible effect

1. Did the investigators claim the effect in the abstract?

Yes

Possible

No

2. Did the investigators claim the effect in the conclusion of abstract?

Possible*

No

No

3. Did the investigators claim the effect in the discussion?

Yes

Possible

Yes

4. Did the investigators use the descriptive words (e.g. appear/seem to be, may, and might) to soften their statements of the claims?

No

Possible

Possible

5. Did the investigators used descriptive words (e.g. particular, and special) to strengthen the statement of the claims

Possible

No

No

6. Were the authors obviously cautious about the apparent subgroup effect? (e.g. they stated the subgroup effect did not meet some of important criteria to believe a subgroup effect)

No

Some caution possible

Yes

7. Did the investigators indicate the apparent effects need to be explored in the future studies (i.e. hypothesis generating)?

No

Possible say desirable to confirm

Yes

  1. * If a claim appears in the conclusion section of the abstract, it is considered a strong claim.