TY - JOUR AU - Sun, Xin AU - Briel, Matthias AU - Busse, Jason W. AU - Akl, Elie A. AU - You, John J. AU - Mejza, Filip AU - Bala, Malgorzata AU - Diaz-Granados, Natalia AU - Bassler, Dirk AU - Mertz, Dominik AU - Srinathan, Sadeesh K. AU - Vandvik, Per Olav AU - Malaga, German AU - Alshurafa, Mohamed AU - Dahm, Philipp AU - Alonso-Coello, Pablo AU - Heels-Ansdell, Diane M. AU - Bhatnagar, Neera AU - Johnston, Bradley C. AU - Wang, Li AU - Walter, Stephen D. AU - Altman, Douglas G. AU - Guyatt, Gordon H. PY - 2009 DA - 2009/11/09 TI - Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials JO - Trials SP - 101 VL - 10 IS - 1 AB - Subgroup analyses in randomized trials examine whether effects of interventions differ between subgroups of study populations according to characteristics of patients or interventions. However, findings from subgroup analyses may be misleading, potentially resulting in suboptimal clinical and health decision making. Few studies have investigated the reporting and conduct of subgroup analyses and a number of important questions remain unanswered. The objectives of this study are: 1) to describe the reporting of subgroup analyses and claims of subgroup effects in randomized controlled trials, 2) to assess study characteristics associated with reporting of subgroup analyses and with claims of subgroup effects, and 3) to examine the analysis, and interpretation of subgroup effects for each study's primary outcome. SN - 1745-6215 UR - https://doi.org/10.1186/1745-6215-10-101 DO - 10.1186/1745-6215-10-101 ID - Sun2009 ER -