Does the Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism modify the response to ACE inhibitor therapy? – A systematic review

Table 1 Internal validity of included randomized controlled trials [20]

	Homogenous study group	Blinding of outcome assessor for genotype	Blinding of outcome assessor for treatment	Blinding of laboratory assessor for outcome	Blinding of treatmen t provider (doctor) for genotype	Blinding of treatment treatment	Blinding of patients for treatment	Check to what extent blinding was successful	Registration of loss to follow-up	Random allocation (description of procedure)	Treatment allocation concealed
Hernandez 2000 [25]	+	+	+	-	-	-	+	-	+	-	-
Hingorani 1997 [26]	+	-	-	-	-	-	-	-	-	+/-	-
Kventy 2000 [27]	+/-	-	-	-	-	+	+	-	+	-	-
Meurice 2001 [28]	+/-	-	-	-	-	+	+	-	+	-	+/-
Okamura 1999 [21]	-	-	-	-	-	-	-	-	+	-	-
Okumura 2002 [29]	+	-	-	+	-	-	-	-	+/-	-	-
Pedersen 1997 [30]	-	+	+	+	-	+	+	-	+	+/-	-
Penno 1998 [23]	+/-	-	-	+/-	-	+	+	-	+	+	+
Perna 1999 [24]	+/-	-	-	-	-	+	+	-	-	+	+
Pinto1995 [31]	-	+	+	+	-	+	+	-	-	-	-
Van Geel 2003 [22]	+	-	-	-	-	-	+	-	-	+/-	-
	Methods for dealing with missing values	Compliance checked	Analysis of CI	Control for possible clinical and other confounders between genotypes	Control of co- interventions that bear on outcome for each genotype	Per protocol analysis	Intention to treat analysis
Hernandez 2000 [25]	-	+/-	-	+	-	-	+
Hingorani 1997 [26]	+/-	-	-	+	-	+/-	-
Kventy 2000 [27]	-	-	-	-	-	-	-
Meurice 2001 [28]	+	+	-	-	+	+	+
Okamura1999 [21]	-	-	-	+/-	+/-	-	-
Okumura 2002 [29]	-	-	-	-	-	+	-
Pedersen 1997 [30]	-	+/-	+/-	-	-	+/-	-
Penno 1998 [23]	+/-	+/-	+	+/-	+/-	+/-	+
Perna 1999 [24]	-	-	-	+/-	-	-	+
Pinto 1995 [31]	-	+	-	-	-	+/-	+
Van Geel 2003 [22]	-	-	-	+/-	-	+/-	-

+ : Fulfilled; +/- : Partially fulfilled; - : Not fulfilled or no information provided

ISSN: 1745-6215