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Table 1 Internal validity of included randomized controlled trials [20]

From: Does the Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism modify the response to ACE inhibitor therapy? – A systematic review

  Homogenous study group Blinding of outcome assessor for genotype Blinding of outcome assessor for treatment Blinding of laboratory assessor for outcome Blinding of treatmen t provider (doctor) for genotype Blinding of treatment treatment Blinding of patients for treatment Check to what extent blinding was successful Registration of loss to follow-up Random allocation (description of procedure) Treatment allocation concealed
Hernandez 2000 [25] + + + - - - + - + - -
Hingorani 1997 [26] + - - - - - - - - +/- -
Kventy 2000 [27] +/- - - - - + + - + - -
Meurice 2001 [28] +/- - - - - + + - + - +/-
Okamura 1999 [21] - - - - - - - - + - -
Okumura 2002 [29] + - - + - - - - +/- - -
Pedersen 1997 [30] - + + + - + + - + +/- -
Penno 1998 [23] +/- - - +/- - + + - + + +
Perna 1999 [24] +/- - - - - + + - - + +
Pinto1995 [31] - + + + - + + - - - -
Van Geel 2003 [22] + - - - - - + - - +/- -
  Methods for dealing with missing values Compliance checked Analysis of CI Control for possible clinical and other confounders between genotypes Control of co- interventions that bear on outcome for each genotype Per protocol analysis Intention to treat analysis     
Hernandez 2000 [25] - +/- - + - - +     
Hingorani 1997 [26] +/- - - + - +/- -     
Kventy 2000 [27] - - - - - - -     
Meurice 2001 [28] + + - - + + +     
Okamura1999 [21] - - - +/- +/- - -     
Okumura 2002 [29] - - - - - + -     
Pedersen 1997 [30] - +/- +/- - - +/- -     
Penno 1998 [23] +/- +/- + +/- +/- +/- +     
Perna 1999 [24] - - - +/- - - +     
Pinto 1995 [31] - + - - - +/- +     
Van Geel 2003 [22] - - - +/- - +/- -     
  1. + : Fulfilled; +/- : Partially fulfilled; - : Not fulfilled or no information provided