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Table 1 Study Inclusion and Exclusion Criteria

From: The clopidogrel after surgery for coronary artery disease (CASCADE) randomized controlled trial: clopidogrel and aspirin versus aspirin alone after coronary bypass surgery [NCT00228423]

Inclusion Criteria: Reason:
- Patients undergoing primary multi-vessel CABG with at least two saphenous vein grafts, with or without cardiopulmonary bypass - The population of clinical interest
Preoperative Exclusion Criteria: Reason:
- Emergency surgery - Unable to obtain consent
- Valve surgery - Requirement of postoperative anticoagulation
- Redo CABG - Higher risk of postoperative bleeding and low cardiac output syndrome
- Left ventricle ejection fraction <25% - Higher risk of postoperative low cardiac output syndrome and mortality
- Serum creatinine >130 ╬╝mol/L - Contraindication to use of postoperative angiography
- Preoperative use of clopidogrel (with the exception of the current admission) - Contraindication to randomization, confounding of results
- Preoperative use of warfarin - Requirement of postoperative anticoagulation
- Allergy to aspirin or clopidogrel - Contraindication to use of aspirin or clopidogrel
- History of cerebrovascular accident - Concurrent indication for clopidogrel
- History of severe liver disease - Contraindication to use of clopidogrel
- Morbid obesity - Unable to perform postoperative angiography
- Residence outside of Ottawa region - Unable to perform postoperative angiography
- Current malignancy - Higher risk of early postoperative mortality
- Inability to provide informed consent - Ineligible for research study enrollment
Postoperative Exclusion Criteria: Reason:
- Low cardiac output syndrome with inotropic support for greater than 24 hours - Unstable patient unlikely to benefit from treatment
- Recurrent ventricular arrhythmias - Unstable patient unlikely to benefit from treatment
- Intubation for more than 24 hours - Unstable patient unlikely to benefit from treatment
- Postoperative bleeding or cardiac tamponade requiring surgical exploration - Contraindication to use of clopidogrel
- Postoperative gastrointestinal bleeding - Contraindication to use of clopidogrel
- Postoperative warfarin requirement - Contraindication to use of clopidogrel