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  1. Study protocol

    Real versus sham proximal biofield therapy in the treatment of warts of the hands and feet in adults: study protocol for a randomized controlled trial (MAGNETIK study)

    Despite the lack of scientific studies on biofield therapies, they are widely acclaimed by patients. The mechanisms of action are not explained by current allopathic medical approaches. Warts are common and co...

    Cathy Gaillard, Laure Allain, Hélène Legros, Sylvie Brucato, Yohann Desgue, Christophe Rouillon, Laure Peyro-Saint-Paul and Anne Dompmartin

    Trials 2017 18:263

    Published on: 7 June 2017

  2. Study protocol

    Impact of community-initiated Kangaroo Mother Care on survival of low birth weight infants: study protocol for a randomized controlled trial

    Around 70% neonatal deaths occur in low birth weight (LBW) babies. Globally, 15% of babies are born with LBW. Kangaroo Mother Care (KMC) appears to be an effective way to reduce mortality and morbidity among L...

    Sarmila Mazumder, Sunita Taneja, Suresh Kumar Dalpath, Rakesh Gupta, Brinda Dube, Bireshwar Sinha, Kiran Bhatia, Sachiyo Yoshida, Ole Frithjof Norheim, Rajiv Bahl, Halvor Sommerfelt, Nita Bhandari and Jose Martines

    Trials 2017 18:262

    Published on: 7 June 2017

  3. Study protocol

    Different strategies for mechanical VENTilation during CardioPulmonary Bypass (CPBVENT 2014): study protocol for a randomized controlled trial

    There is no consensus on which lung-protective strategies should be used in cardiac surgery patients. Sparse and small randomized clinical and animal trials suggest that maintaining mechanical ventilation duri...

    Elena Bignami, Marcello Guarnieri, Francesco Saglietti, Enivarco Massimo Maglioni, Sabino Scolletta, Stefano Romagnoli, Stefano De Paulis, Gianluca Paternoster, Cinzia Trumello, Roberta Meroni, Antonio Scognamiglio, Alessandro Maria Budillon, Vincenzo Pota, Alberto Zangrillo and Ottavio Alfieri

    Trials 2017 18:264

    Published on: 7 June 2017

  4. Study protocol

    The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial

    The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of cardamom have been found in some studies. Cardamom sh...

    Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani and Gity Sotoudeh

    Trials 2017 18:260

    Published on: 7 June 2017

  5. Study protocol

    Comparing counselling models for the hazardous use of alcohol at the Swedish National Alcohol Helpline: study protocol for a randomised controlled trial

    Hazardous and harmful consumption of alcohol is a leading cause of preventable disease and premature deaths. Modifying the amount and pattern of risky alcohol consumption conveys substantial benefits to indivi...

    Eleonor Säfsten, Yvonne Forsell, Mats Ramstedt and Maria Rosaria Galanti

    Trials 2017 18:257

    Published on: 6 June 2017

  6. Study protocol

    A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial

    Delayed graft function (DGF) is traditionally defined as the requirement for dialysis during the first week after transplantation. DGF is a common complication of renal transplantation, and it negatively affec...

    Theodoros Kassimatis, Anass Qasem, Abdel Douiri, Elizabeth G. Ryan, Irene Rebollo-Mesa, Laura L. Nichols, Roseanna Greenlaw, Jonathon Olsburgh, Richard A. Smith, Steven H. Sacks and Martin Drage

    Trials 2017 18:255

    Published on: 6 June 2017

  7. Update

    COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures (CODES): statistical and economic analysis plan for a randomised controlled trial

    Dissociative seizures (DSs), also called psychogenic non-epileptic seizures, are a distressing and disabling problem for many patients in neurological settings with high and often unnecessary economic costs. The ...

    Emily J. Robinson, Laura H. Goldstein, Paul McCrone, Iain Perdue, Trudie Chalder, John D. C. Mellers, Mark P. Richardson, Joanna Murray, Markus Reuber, Nick Medford, Jon Stone, Alan Carson and Sabine Landau

    Trials 2017 18:258

    Published on: 6 June 2017

  8. Study protocol

    Hypertension with unsatisfactory sleep health (HUSH): study protocol for a randomized controlled trial

    Insomnia is common in primary care medical practices. Although behavioral treatments for insomnia are safe, efficacious, and recommended in practice guidelines, they are not widely-available, and their effects...

    Jessica C. Levenson, Bruce L. Rollman, Lee M. Ritterband, Patrick J. Strollo, Kenneth J. Smith, Jonathan G. Yabes, Charity G. Moore, Allison G. Harvey and Daniel J. Buysse

    Trials 2017 18:256

    Published on: 6 June 2017

  9. Study protocol

    Influences of De Qi induced by acupuncture on immediate and accumulated analgesic effects in patients with knee osteoarthritis: study protocol for a randomized controlled trial

    De Qi is a special sensational response upon acupuncture needling. According to traditional acupuncture theory, the treatment is “effective only after Qi arrival”; that is, De Qi is an...

    Min Li, Hongwen Yuan, Pei Wang, Siyuan Xin, Jie Hao, Miaomiao Liu, Jinfeng Li, Man Yu and Xinrui Zhang

    Trials 2017 18:251

    Published on: 5 June 2017

  10. Study protocol

    Live birth after fresh versus frozen single blastocyst transfer (Frefro-blastocyst): study protocol for a randomized controlled trial

    Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to r...

    Daimin Wei, Yun Sun, Jiayin Liu, Xiaoyan Liang, Yimin Zhu, Yuhua Shi and Zi-Jiang Chen

    Trials 2017 18:253

    Published on: 5 June 2017

  11. Study protocol

    Fatigue mitigation with SleepTrackTXT2 in air medical emergency care systems: study protocol for a randomized controlled trial

    Most air medical Emergency Medical Services (EMS) clinicians work extended duration shifts, and more than 50% report inadequate sleep, poor sleep quality, and/or poor recovery between shifts. The SleepTrackTXT...

    P. Daniel Patterson, Charity G. Moore, Frank X. Guyette, Jack M. Doman, Denisse Sequeira, Howard A. Werman, Doug Swanson, David Hostler, Joshua Lynch, Lindsey Russo, Linda Hines, Karen Swecker, Michael S. Runyon and Daniel J. Buysse

    Trials 2017 18:254

    Published on: 5 June 2017

  12. Study protocol

    Acute and chronic effects of aerobic exercise on blood pressure in resistant hypertension: study protocol for a randomized controlled trial

    Resistant hypertension is a specific condition that affects approximately 10% of subjects with hypertension, and is characterized by persistently high blood pressure levels even using therapy of three or more ...

    LS Nascimento, AC Santos, JMS Lucena, LGO Silva, AEM Almeida and MS Brasileiro-Santos

    Trials 2017 18:250

    Published on: 2 June 2017

  13. Study protocol

    Effectiveness of additional trunk exercises on gait performance: study protocol for a randomized controlled trial

    Evidence is lacking concerning the effect of additional trunk rehabilitation on gait performance. Investigating gait performance by both clinical and biomechanical outcome measures might lead to new scientific...

    Tamaya Van Criekinge, Wim Saeys, Ann Hallemans, Luc Vereeck, Willem De Hertogh, Patricia Van de Walle, Nathalie Vaes, Christophe Lafosse and Steven Truijen

    Trials 2017 18:249

    Published on: 2 June 2017

  14. Erratum

    Erratum to Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

    T. Bluth, R. Teichmann, T. Kiss, I. Bobek, J. Canet, G. Cinnella, L. De Baerdemaeker, C. Gregoretti, G. Hedenstierna, S. N. Hemmes, M. Hiesmayr, M. W. Hollmann, S. Jaber, J. G. Laffey, M. J. Licker, K. Markstaller…

    Trials 2017 18:247

    Published on: 1 June 2017

    The original article was published in Trials 2017 18:202

  15. Study protocol

    Does an 8-week home-based exercise program affect physical capacity, quality of life, sick leave, and use of psychotropic drugs in patients with pulmonary embolism? Study protocol for a multicenter randomized clinical trial

    The existing evidence base in pulmonary embolism (PE) is primarily focused on diagnostic methods, medical treatment, and prognosis. Only a few studies have investigated how everyday life is affected by PE, alt...

    Nanna Rolving, Barbara C. Brocki, Hanne R. Mikkelsen, Pernille Ravn, Jannie Rhod Bloch-Nielsen and Lars Frost

    Trials 2017 18:245

    Published on: 30 May 2017

  16. Study protocol

    Determining the impact of 24/7 phone support on hospital readmissions after aortic valve replacement surgery (the AVRre study): study protocol for a randomised controlled trial

    Patients undergoing surgical aortic valve replacement (sAVR) have high rates of 30-day readmissions. They also report a low health-related quality of life (HRQOL) and elevated anxiety and depression. The aim o...

    Irene Lie, Stein Ove Danielsen, Theis Tønnessen, Svein Solheim, Marit Leegaard, Leiv Sandvik, Torbjørn Wisløff, Jonny Vangen, Tor Henning Røsstad and Philip Moons

    Trials 2017 18(Suppl 2):246

    Published on: 30 May 2017

    This article is part of a Supplement: Volume 18 Supplement 2

  17. Study protocol

    Anesthetic management of cesarean section in cases of placenta accreta, with versus without abdominal aortic balloon occlusion: study protocol for a randomized controlled trial

    Placenta accreta (PA), a severe complication during delivery, is closely linked with massive hemorrhage which could endanger the lives of both mother and baby. Moreover, the incidence of PA has increased drama...

    Qinjun Chu, Dan Shen, Long He, Hongwei Wang, Xianlan Zhao, Zhimin Chen, Yanli Wang and Wei Zhang

    Trials 2017 18:240

    Published on: 26 May 2017

  18. Study protocol

    The Shared Health Appointments and Reciprocal Enhanced Support (SHARES) study: study protocol for a randomized trial

    Diabetes shared medical appointments (SMAs) and reciprocal peer support programs have been found in efficacy trials to help adults with diabetes improve their self-management and achieve short-term gains in cl...

    Michele Heisler, Jennifer Burgess, Jeffrey Cass, John F. Chardos, Alexander B. Guirguis, Sean M. Jeffery, Lorrie A. Strohecker, Adam S. Tremblay, Wen-Chih Wu and Donna M. Zulman

    Trials 2017 18:239

    Published on: 26 May 2017

  19. Study protocol

    The effects of a psychological intervention directed at optimizing immune function: study protocol for a randomized controlled trial

    Previous research has provided evidence for the link between psychological processes and psychophysiological health outcomes. Psychological interventions, such as face-to-face or online cognitive behavioral th...

    Lemmy Schakel, Dieuwke S. Veldhuijzen, Henriët van Middendorp, Corine Prins, Simone A. Joosten, Tom H. M. Ottenhoff, Leo G. Visser and Andrea W. M. Evers

    Trials 2017 18:243

    Published on: 26 May 2017

  20. Study protocol

    Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial

    Haemorrhage is a leading cause of death in severe trauma. Fibrinogen plays a critical role in maintaining haemostasis in traumatic haemorrhage. Early fibrinogen replacement is recommended by several internatio...

    James Winearls, Martin Wullschleger, Elizabeth Wake, Catherine Hurn, Jeremy Furyk, Glenn Ryan, Melita Trout, James Walsham, Anthony Holley, Jeremy Cohen, Megan Shuttleworth, Wayne Dyer, Gerben Keijzers, John F Fraser, Jeffrey Presneill and Don Campbell

    Trials 2017 18:241

    Published on: 26 May 2017

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