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  1. Adolescence is a period of heightened vulnerability to developing mental health problems, and rates of mental health disorder in this age group have increased in the last decade. Preventing mental health probl...

    Authors: Essi Viding, Alex Lloyd, Roslyn Law, Peter Martin, Laura Lucas, Tom Chin-Han Wu, Nikolaus Steinbeis, Nick Midgley, René Veenstra, Jaime Smith, Lili Ly, Geoffrey Bird, Jennifer Murphy, David Plans, Marcus Munafo, Ian Penton-Voak…
    Citation: Trials 2024 25:143
  2. Seroma after breast cancer surgery is a frequent entity; therefore, different products have been described in literature with the aim to reduce it. The most studied ones have been the sealants products, being ...

    Authors: Sandra López Gordo, Neus Ruiz-Edo, Maria Teresa Fernández-Planas, Sara Viscaya-Martín and Cristina Serra-Serra
    Citation: Trials 2024 25:142
  3. Over 3000 young people under the age of 18 are admitted to Tier 4 Child and Adolescent Mental Health Services (CAMHS) inpatient units across the UK each year. The average length of hospital stay for young peop...

    Authors: Thilipan Thaventhiran, Ben Hoi-Ching Wong, Izabela Pilecka, Saba Masood, Opeyemi Atanda, Joe Clacey, Jovanka Tolmac, Leon Wehncke, Liana Romaniuk, Margaret Heslin, Emma Tassie, Petrina Chu, Rhys Bevan-Jones, Ruth Woolhouse, Tauseef Mahdi, Veronika Beatrice Dobler…
    Citation: Trials 2024 25:141
  4. Vision is an important and defining element of laparoscopy and significantly affects the outcome of surgery in terms of time, error, and precision. Several new imaging systems have become available for laparos...

    Authors: Tibor A. Zwimpfer, Nadja Stiegeler, Philip C. Müller, Andreas Schötzau, Bernhard Fellmann-Fischer, Viola Heinzelmann-Schwarz, Ralph Peterli and Marko Kraljević
    Citation: Trials 2024 25:140
  5. Trial method research produces recommendations on how to best conduct trials. However, findings are not routinely implemented into practice. To better understand why, we conducted a mixed method study on the c...

    Authors: Taylor Coffey, Paula R. Williamson and Katie Gillies
    Citation: Trials 2024 25:139
  6. Cornea is the most important refractive media in the eye, and damage to the corneal endothelium is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with pr...

    Authors: Soujanya Kaup, Dimple Kondal, Siddharudha Shivalli and John Buchan
    Citation: Trials 2024 25:138
  7. The advantages of laparoscopic left-sided hepatectomy (LLH) for treating hepatolithiasis in terms of the time to postoperative length of hospital stay (LOS), morbidity, long-term abdominal wall hernias, hospit...

    Authors: Shu-bo Pan, Chun-li Wu, Da-chen Zhou, Qi-ru Xiong, Xiao-ping Geng and Hui Hou
    Citation: Trials 2024 25:137
  8. The continual development and implementation of effective digital interventions is one important strategy that may serve to bridge the well-known treatment gap related to problematic alcohol use. Research sugg...

    Authors: Christopher Sundström, Ekaterina Ivanova, Philip Lindner, Magnus Johansson and Martin Kraepelien
    Citation: Trials 2024 25:136
  9. Rotator cuff (RC) tendinopathy is the most reported shoulder disorder in the general population with highest prevalence in overhead athletes and adult working-age population. A growing body of evidence support...

    Authors: Birgitte Hougs Kjær, Ann M. Cools, Finn E. Johannsen, Jeanette Trøstrup, Theresa Bieler, Volkert Siersma and Peter S. Magnusson
    Citation: Trials 2024 25:135
  10. Emotional blunting is a symptom that has always been present in depressed patients. Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective supplementary therapy for treating depression. Ho...

    Authors: Yuyu Zhang, Nailong Tang, Lei Lei, Runxin Lv, Yaochi Zhang, Nian Liu, Haixia Chen, Min Cai and Huaning Wang
    Citation: Trials 2024 25:134
  11. Patients with cervical spondylosis myelopathy (CSM) may experience severe neurological dysfunction due to untimely spinal cord compression after surgery. These disorders may lead to sensory and motion disorder...

    Authors: Jiajun Wu, Zhongchuan Sun, Zhichao Ge, Dong Zhang, Jianghan Xu, Rilin Zhang, Xuecheng Liu, Qing Zhao and Hao Sun
    Citation: Trials 2024 25:133
  12. Nowadays, large benign lateral spreading lesions (LSLs) and sessile polyps in the colorectum are mostly resected by endoscopic mucosal resection (EMR). A major drawback of EMR is the polyp recurrence rate of u...

    Authors: Gijs Kemper, Christian Gerges, Erik J. Schoon, Ramon-Michel Schreuder, Ruud R. W. Schrauwen, Ludger S. M. Epping, Torsten Beyna, Joost P. H. Drenth, Ufuk Gündug, Peter D. Siersema and Erwin J. M. van Geenen
    Citation: Trials 2024 25:132
  13. We evaluated the clinical and cost-effectiveness of manualised sensory integration therapy (SIT) for autistic children with sensory processing difficulties in a two-arm randomised controlled trial. Trial proce...

    Authors: Elizabeth Randell, Rachel McNamara, Monica Busse, Sue Delport, Rhys Williams-Thomas, Wakunyambo Maboshe, David Gillespie, Sarah Milosevic, Lucy Brookes-Howell, Melissa Wright, Richard P. Hastings, Anne Marie McKigney, Eleni Glarou and Alka Ahuja
    Citation: Trials 2024 25:131
  14. Lung cancer is the most common cancer in China, with the highest mortality rate. Surgery is the primary treatment for early lung cancer. However, patients with lung cancer have a heavy burden of symptoms withi...

    Authors: Ying Liang, Pengyu Jing, Zhongping Gu, Lei Shang, Peng Ge, Yong Zhang, Lv Wang, Chun Qiu, Ximing Zhu and Zhijun Tan
    Citation: Trials 2024 25:130
  15. The guidelines of the American Diabetes Association and European Association for the Study of Diabetes suggest that patients with obesity type 2 diabetics and chronic kidney disease need either glucagon-like p...

    Authors: Ebaa Al-Ozairi, Kavita Narula, Alexander D. Miras, Etab Taghadom, Abeer El Samad, Jumana Al Kandari, Anas Alyosef, Anant Mashankar, Werd Al-Najim and Carel W. le Roux
    Citation: Trials 2024 25:129
  16. Transfer of severely injured patients to trauma centers, either directly from the field or after evaluation at non-trauma centers, reduces preventable morbidity and mortality. Failure to transfer these patien...

    Authors: Deepika Mohan, Derek C. Angus, Chung-Chou H. Chang, Jonathan Elmer, Baruch Fischhoff, Kim J. Rak, Jacqueline L. Barnes, Andrew B. Peitzman and Douglas B. White
    Citation: Trials 2024 25:127
  17. Vancomycin is a commonly prescribed antibiotic to treat gram-positive infections. The efficacy of vancomycin is known to be directly related to the pharmacokinetic/pharmacodynamic (PK/PD) index of the area un...

    Authors: Glenn Van Wynsberge, Veerle Grootaert, Franky Buyle, Jens Van Praet, Roos Colman, Ine Moors, Annemie Somers, Diana Huis in ‘t Veld and Pieter De Cock
    Citation: Trials 2024 25:126
  18. As part of the German Medical Informatics Initiative, the MIRACUM project establishes data integration centers across ten German university hospitals. The embedded MIRACUM Use Case “Alerting in Care - IT Suppo...

    Authors: Martin Boeker, Daniela Zöller, Romina Blasini, Philipp Macho, Sven Helfer, Max Behrens, Hans-Ulrich Prokosch and Christian Gulden
    Citation: Trials 2024 25:125
  19. Persons with opioid use disorders who inject drugs (PWID) in the United States (US) face multiple and intertwining health risks. These include interference with consistent access, linkage, and retention to hea...

    Authors: David Goodman-Meza, Steven Shoptaw, Brett Hanscom, Laramie R. Smith, Philip Andrew, Irene Kuo, Jordan E. Lake, David Metzger, Ellen A. B. Morrison, Melissa Cummings, Jessica M. Fogel, Paul Richardson, Jayla Harris, Jesse Heitner, Sarah Stansfield and Nabila El-Bassel
    Citation: Trials 2024 25:124
  20. Currently, there is no evidence-based hormonal treatment for migraine in women. Several small studies suggest a beneficial effect of combined oral contraceptives, but no large randomized controlled trial has b...

    Authors: Britt W. H. van der Arend, Daphne S. van Casteren, Iris E. Verhagen, Antoinette MaassenVanDenBrink and Gisela M. Terwindt
    Citation: Trials 2024 25:123
  21. Anorectal fistula, which is a relatively common pathology, is the chronic manifestation of the acute perirectal process that forms an anal abscess. The development of a fistula after incision and drainage of a...

    Authors: Verónica Polaino Moreno, Antonio F. Caballero-Bermejo, Mariano Artés Caselles, Javier Serrano González, Xabier Remírez Arriaga, Natalia González Alcolea, Aritz Equisoain Azcona, Eva Iglesias García, José Luis Lucena de la Poza, Arsenio Sánchez Movilla and Belén Ruiz-Antorán
    Citation: Trials 2024 25:122
  22. In Germany, approximately half a million people are diagnosed with cancer annually; this can be traumatic and lead to depression, anxiety, and adjustment disorders necessitating psycho-oncological intervention...

    Authors: Maren Reder, Christine Hofheinz, Lena Melzner, Gabriele Prinz and Christoph Kröger
    Citation: Trials 2024 25:121
  23. Autosomal dominant polycystic kidney disease (ADPKD) leads to progressive renal cyst formation and loss of kidney function in most patients. Vasopressin 2 receptor antagonists (V2RA) like tolvaptan are current...

    Authors: Thomas Bais, Esther Meijer, Bart J. Kramers, Priya Vart, Marc Vervloet, Mahdi Salih, Bert Bammens, Nathalie Demoulin, Polina Todorova, Roman-Ulrich Müller, Jan Halbritter, Alexander Paliege, Emilie Cornec-Le Gall, Bertrand Knebelmann, Roser Torra, Albert C. M. Ong…
    Citation: Trials 2024 25:120
  24. Evidence-based parenting programmes have strong evidence in preventing and mitigating violence, but in-person programmes are challenging to deliver at scale. ParentApp is an open-source, offline-first app-base...

    Authors: Lauren Baerecke, Abigail Ornellas, Joyce Wamoyi, Mwita Wambura, Jonathan Klapwijk, Angelique N. Chetty, Ashlin Simpson, Roselinde Janowski, Kristen de Graaf, David Stern, Lily Clements, Esmee te Winkel, Laetitia Christine, Gervas Mbosoli, Kija Nyalali, Onduru Gervas Onduru…
    Citation: Trials 2024 25:119
  25. Out-of-hospital cardiac arrest (OHCA) is a significant public health issue worldwide and is associated with low survival rates and poor neurological outcomes. The generation of optimal coronary perfusion press...

    Authors: Hee Eun Kim, Sheng-En Chu, You Hwan Jo, Wen-Chu Chiang, Dong-Hyun Jang, Chin-Hao Chang, So Hee Oh, Hsuan-An Chen, Seung Min Park, Jen-Tang Sun and Dong Keon Lee
    Citation: Trials 2024 25:118
  26. Pragmatic trials evaluating complex health interventions often compare them to usual care. This comparator should resemble care as provided in everyday practice. However, usual care can differ for the same con...

    Authors: Katrina M. Turner, Alyson Huntley, Tom Yardley, Sarah Dawson and Shoba Dawson
    Citation: Trials 2024 25:117
  27. Non-suicidal self-injury (NSSI) is a growing healthcare problem. Individuals with NSSI have an increased risk of suicidality. Due to stigma, they may self-injure in secret, which means they might not seek help...

    Authors: Evelyn Guerrero, Kate Andreasson, Lene Larsen, Niels Buus, Jette Louise Skovgaard Larsen, Jesper Krogh, Rasmus Thastum, Lone Lindberg, Katrine Lindblad, Annette Erlangsen and Merete Nordentoft
    Citation: Trials 2024 25:116
  28. The high incidence combined with the high lethality and bad prognosis of lung cancer highlight the need for psycho-oncological care for both patients and their relatives. While psychological interventions for ...

    Authors: Julia Dusel, Karin Meng, Hanna Arnold, Antonia Rabe and Elisabeth Jentschke
    Citation: Trials 2024 25:115
  29. Economic incentives can improve clinical outcomes among in-care people living with HIV (PLHIV), but evidence is limited for their effectiveness among out-of-care PLHIV or those at risk of disengagement. We pro...

    Authors: Jillian L. Kadota, Laura J. Packel, Matilda Mlowe, Nzovu Ulenga, Natalino Mwenda, Prosper F. Njau, William H. Dow, Jingshen Wang, Amon Sabasaba and Sandra I. McCoy
    Citation: Trials 2024 25:114
  30. Statisticians are fundamental in ensuring clinical research, including clinical trials, are conducted with quality, transparency, reproducibility and integrity. Good Clinical Practice (GCP) is an international...

    Authors: Deborah D. Stocken, Helen Mossop, Emma Armstrong, Steff Lewis, Susan J. Dutton, Claire Peckitt, Carrol Gamble and Julia Brown
    Citation: Trials 2024 25:113
  31. Depression continues to be an ongoing threat to adolescent well-being with Black adolescents being particularly vulnerable to greater burdens of depression as well as lower mental health service utilization. B...

    Authors: Michael A. Lindsey, Laura Mufson, Carolina Vélez-Grau, Tracy Grogan, Damali M. Wilson, Aaron O. Reliford, Meredith Gunlicks-Stoessel and James Jaccard
    Citation: Trials 2024 25:112
  32. Authors: Russell J. McCulloh, Paul M. Darden, Jessica Snowden, Songthip Ounpraseuth, Jeannette Lee, Martina Clarke, Sophia R. Newcomer, Linda Fu, DeAnn Hubberd, Jaime Baldner, Maryam Garza and Ellen Kerns
    Citation: Trials 2024 25:111

    The original article was published in Trials 2022 23:911

  33. Preterm and term small for gestational age (SGA) babies are at high risk of experiencing malnutrition and impaired neurodevelopment. Standalone interventions have modest and sometimes inconsistent effects on g...

    Authors: Ranadip Chowdhury, Rukman Manapurath, Ingvild Fossgard Sandøy, Ravi Prakash Upadhyay, Neeta Dhabhai, Saijuddin Shaikh, Harish Chellani, Tarun Shankar Choudhary, Abhinav Jain, Jose Martines, Nita Bhandari, Tor A. Strand and Sunita Taneja
    Citation: Trials 2024 25:110
  34. Improving retention within randomised controlled trials is important. The effectiveness of different strategies can be assessed using a Study Within A Trial (SWAT). Previous research has shown personalised tex...

    Authors: Esther Herbert, Diana Papaioannou, Amanda Loban, Nikki Totton, Marie Hyslop, Robert Bolt and Christopher Deery
    Citation: Trials 2024 25:108
  35. Multicenter trials in orthopedic trauma are costly, yet crucial to advance the science behind clinical care. The number of sites is a key cost determinant. Each site has a fixed overhead cost, so more sites co...

    Authors: Lauren Allen, Robert V. O’Toole, Michael J. Bosse, William T. Obremskey, Kristin R. Archer, Lisa K. Cannada, Jaimie Shores, Lisa M. Reider, Katherine P. Frey, Anthony R. Carlini, Elena D. Staguhn and Renan C. Castillo
    Citation: Trials 2024 25:107
  36. Robotic spinal surgery may result in better pedicle screw placement accuracy, and reduction in radiation exposure and length of stay, compared to freehand surgery. The purpose of this randomized controlled tri...

    Authors: Nicolas Aurouer, Patrick Guerin, Arnaud Cogniet, Nicolas Gangnet, Morad Pedram, Pierre-Thierry Piechaud and Paolo Mangione
    Citation: Trials 2024 25:106
  37. Many research funders have invested billions of US dollars in building research capacity in sub-Saharan Africa (SSA). Despite these colossal investments, many well-intentioned and designed clinical research pr...

    Authors: Yauba Saidu, Sangwe Clovis Nchinjoh, Amani Adidja, Andreas Frambo Besong, Palmer Masumbe Netongo, Paul Ndom and Marya Liebermann
    Citation: Trials 2024 25:105
  38. Neuroimaging studies suggest an association between apathy after deep brain stimulation (DBS) and stimulation of the ventral part of the subthalamic nucleus (STN) due to the associative fibers connected to the...

    Authors: T. J. C. Zoon, G. van Rooijen, M. F. Contarino, S. van der Gaag, R. Zutt, J. T. van Asseldonk, P. van den Munckhof, P. R. Schuurman, D. A. J. P. Denys and R. M. A. de Bie
    Citation: Trials 2024 25:104
  39. Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53. Individuals with LFS have a 70–100% lifetime risk of developing cancer. The cur...

    Authors: Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin…
    Citation: Trials 2024 25:103
  40. Among older people undiagnosed and untreated vision impairment and blindness are common. The leading causes are uncorrected refractive errors and cataracts. Vision problems are associated with a lower quality ...

    Authors: Vera Rooth, Hilde van der Aa, Robert P. L. Wisse, Otto R. Maarsingh, Marc Koopmanschap, Jan E. E. Keunen, Hester Vermeulen, Caroline C. W. Klaver, Gabriëlle Janssen, Ger H. M. B. van Rens and Ruth M. A. van Nispen
    Citation: Trials 2024 25:102
  41. Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compound...

    Authors: Emily B. Hill, Minghua Tang, Julie M. Long, Jennifer F. Kemp, Jamie L. Westcott, Audrey E. Hendricks, Nichole A. Reisdorph, Wayne W. Campbell and Nancy F. Krebs
    Citation: Trials 2024 25:101
  42. Type 2 diabetes mellitus (T2DM) is a common metabolic disease that requires long-term management and treatment. Digital intervention, as an emerging medical model, has been widely used in the treatment of T2DM...

    Authors: Shao Zhong, Jingyi Jiang, Hongying Liu and Ying Pan
    Citation: Trials 2024 25:100
  43. Most cardiac arrest survivors are classified with mild to moderate cognitive impairment; roughly, 50% experience long-term neurocognitive impairment. Postarrest challenges complicate participation in society a...

    Authors: Jan Christensen, Bo Gregers Winkel, Lilli Kirkeskov, Fredrik Folke, Matilde Winther-Jensen, Christine Eckhardt-Bentsen, Jesper Kjærgaard, Christian Hassager and Mette Kirstine Wagner
    Citation: Trials 2024 25:99
  44. Digital interventions offer many possibilities for improving health, as remote interventions can enhance reach and access to underserved groups of society. However, research evaluating digital health intervent...

    Authors: Rebecca A. Krukowski, Kathryn M. Ross, Max J. Western, Rosie Cooper, Heide Busse, Cynthia Forbes, Emmanuel Kuntsche, Anila Allmeta, Anabelle Macedo Silva, Yetunde O. John-Akinola and Laura M. König
    Citation: Trials 2024 25:98
  45. Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on th...

    Authors: Ming-Hui Lai, Xiao-Ming Yu, Yan Lu, Hong-Lin Wang, Wang Fu, Huan-Xia Zhou, Yuan-Li Li, Jun Hu, Jiayi Xia, Zekai Hu, Chun-Lei Shan, Feng Wang and Cong Wang
    Citation: Trials 2024 25:97
  46. Despite the critical importance of clinical trials to provide evidence about the effects of intervention for children and youth, a paucity of published high-quality pediatric clinical trials persists. Sub-opti...

    Authors: Ami Baba, Maureen Smith, Beth K. Potter, An-Wen Chan, David Moher and Martin Offringa
    Citation: Trials 2024 25:96
  47. Healthcare systems data (HSD) has the potential to optimise the efficiency of randomised controlled trials (RCTs), by decreasing trial-specific data demands. Therefore, the use of HSD in trials is expected to ...

    Authors: Alice-Maria Toader, Carrol L. Gamble, Susanna Dodd and Paula R. Williamson
    Citation: Trials 2024 25:95
  48. The menstrual cycle and its impact on training and performance are of growing interest. However, evidence is lacking whether periodized exercise based on the menstrual cycle is beneficial. The primary purpose ...

    Authors: Linda Ekenros, Philip von Rosen, Jessica Norrbom, Hans-Christer Holmberg, Carl Johan Sundberg, Cecilia Fridén and Angelica Lindén Hirschberg
    Citation: Trials 2024 25:93

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