Australasian Malignant PLeural Effusion (AMPLE)-4 trial: study protocol for a multi-centre randomised trial of topical antibiotics prophylaxis for infections of indwelling pleural catheters

Table 1 Schedule of treatment for each visit and follow-up procedures

	Study period
	Pre-procedure		Post-procedure
	Enrolment	Index procedure	Days post-procedure	Week^a
Timepoint	*Baseline*	D0	D1 ± *24 h*	*1–24*
Enrolment:
Informed consent	X
Baseline data collection	X
Randomisation	X
IPC insertion		X
Interventions
Dressing change ± mupirocin application			X	X
Assessments:
Phone call/clinic visit				X
Adverse event review			X	X
Evaluation of exit-site			X	X

^aWeekly follow-up for up to 6 months (monthly if IPC is removed); IPC, indwelling pleural catheter

ISSN: 1745-6215