The Diaphragmatic Initiated Ventilatory Assist (DIVA) trial: study protocol for a randomized controlled trial comparing rates of extubation failure in extremely premature infants undergoing extubation to non-invasive neurally adjusted ventilatory assist versus non-synchronized nasal intermittent positive pressure ventilation

Table 4 Sample size requirements for the primary outcome

Power	Failure rate in non-synchronized NIPPV arm	Failure rate in NIV-NAVA arm	GSD sample size	ICC	Design effect	Sample size (total infants randomized)
90%	30%	15%	358	0.4	1.10	402
		15%	358	0.6	1.15	422
		20%	844	0.4	1.10	948
		20%	844	0.6	1.15	992
	35%	15%	222	0.4	1.10	250
		15%	222	0.6	1.15	262
		20%	406	0.4	1.10	456
		20%	406	0.6	1.15	478
	40%	15%	154	0.4	1.10	174
		15%	154	0.6	1.15	182
		20%	246	0.4	1.10	278
		20%	246	0.6	1.15	290

ISSN: 1745-6215