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Table 5 Immunogenicity of an alternative versus standard schedule of PCV13 at 18 months of age

From: Pneumococcal conjugate vaccination schedules in infants—acquisition, immunogenicity, and pneumococcal conjugate and yellow fever vaccine co-administration study: statistical analysis plan

 

Geometric mean concentration

Geometric mean concentration ratio (primary outcome)

Proportion of participants with IgG concentration ≥ 0.35 μg/ml

Proportions risk ratio

Serotype

Alternative schedule (N = x)

Standard schedule (N = y)

Alternative vs standard schedule

Alternative schedule (N = x)

Standard schedule (N = y)

Alternative vs standard schedule

μg/ml (95% CI)

μg/ml (95% CI)

x (95% CI)

% (95% CI)

% (95% CI)

X (95% CI)

1

      

3

      

4

      

5

      

6A

      

6B

      

7F

      

9 V

      

14

      

18C

      

19A

      

19F

      

23F

      
  1. Alternative schedule (doses scheduled at age 6 weeks and 9 months). Standard schedule (doses scheduled at age 6, 10, and 14 weeks). Data are from a per protocol cohort
  2. PCV13 13-valent pneumococcal conjugate vaccine