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Table 2 Angiotensin II titration scheme for angiotensin II arm

From: The scientific rationale and study protocol for the DPP3, Angiotensin II, and Renin Kinetics in Sepsis (DARK-Sepsis) randomized controlled trial: serum biomarkers to predict response to angiotensin II versus standard-of-care vasopressor therapy in the treatment of septic shock

Norepinephrine (mcg/kg/min)

Angiotensin II (ng/kg/min)

 < 0.05

5a

0.05–0.1

10

0.11–0.20

20b

0.21–0.25

25

0.26–0.30

30

0.31–0.35

35

 > 0.35

40 (max)

  1. aAngiotensin II doses of 2.5 and 1.25 ng/kg/min can be used when vasopressors are being weaned. bThe starting dose of angiotensin II per the U.S. Food and Drug Administration Prescribing Information is 20 ng/kg/min. When vasopressors are being weaned within these displayed ranges, norepinephrine should be weaned before angiotensin II
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ISSN: 1745-6215