Table 1 Contra-indications and cautions to HCQ or chloroquine use

Current diagnosis of:

Maculopathy of the eye

Hypersensitivity to 4-aminoquinoline compounds

Porphyria

Psoriasis

Severe gastrointestinal disorders (such as inflammatory bowel disease)

Severe neurological disorders

Severe blood disorders

Epilepsy

Diabetes mellitus on pharmacological treatment

Sensitivity to quinine

G6PD deficiency

Concurrent use of:

Agalsidase

Halofantrine

Phenobarbital

Refapentine

Carbamazepine

Monoamine oxidase inhibitors

Phenytoin

Rifampicin

Cisapride

Metamizole

Praziquantel

St John’s wort

Cyclosporin

Mexiletine

Primidone

Tamoxifen

Digoxin

Neostigmine

Pyridostigmine