Uncertainty as research question | Evidence reviewed (878 screened, 76 full text, 34 extracted) |
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1. How can randomised trials become part of routine care and best utilise current clinical care pathways? | • No evidence available |
2. What information should trialists communicate to members of the public who are being invited to take part in a randomised trial in order to improve recruitment to the trial? | • No evidence available |
3. Does patient/public involvement in planning a randomised trial improve recruitment? | • No evidence available |
4. What are the best approaches for designing and delivering information to members of the public who are invited to take part in a randomised trial? | • Bonevski, B.; Randell, M.; Paul, C.; Chapman, K.; Twyman, L.; Bryant, J.; Brozek, I.; Hughes, C. Reaching the hard-to-reach: a systematic review of strategies for improving health and medical research with socially disadvantaged groups. BMC Medical Research Methodology 2014; 14:42. • Synnot, A.; Ryan, R.; Prictor, M.; Fetherstonhaugh, D.; Parker, B.Audio-visual presentation of information for informed consent for participation in clinical trials. Cochrane Database of Systematic Reviews 2014;9(5):CD003717. • Treweek, S.; Lockhart, P.; Pitkethly, M.; Cook, J. A.; Kjeldstrom, M.; Johansen, M.; Taskila, T. K.; Sullivan, F. M.; Wilson, S.; Jackson, C.; Jones, R.; Mitchell, E. D. Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis. BMJ Open 2013;3(2): |
5. What are the barriers and enablers for clinicians/healthcare professionals in helping conduct randomised trials? | • Newington, L.; Metcalfe, A. Researchers’ and clinicians’ perceptions of recruiting participants to clinical research: a thematic meta-synthesis. Journal of Clinical Medicine Research 2014;6(3):162-72 |
6. What are the key motivators influencing members of the public’s decisions to take part in a randomised trial? | • Limkakeng Limkakeng, A.; Phadtare, A.; Shah, J.; Vaghasia, M.; Wei, D. Y.; Shah, A.; Pietrobon, R.Willingness to participate in clinical trials among patients of Chinese heritage: a meta-synthesis. PLoS ONE [Electronic Resource] 2013; 8(1):e51328. • Nalubega, S.; Evans, C. Participant views and experiences of participating in HIV research in sub-Saharan Africa: a qualitative systematic review. JBI Database Of Systematic Reviews And Implementation Reports 2015;13(5):330-420 • Rivers, D.; August, E. M.; Sehovic, I.; Lee Green, B.; Quinn, G. P. A systematic review of the factors influencing African Americans’ participation in cancer clinical trials. Contemporary Clinical Trials 2013;35(2):13-32 • Wilman, E.; Megone, C.; Oliver, S.; Duley, L.; Gyte, G.; Wright, J. M.The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the empirical research.Trials [Electronic Resource] 2015;16:502 |
7. What are the best approaches to ensure inclusion and participation of under-represented or vulnerable groups in randomised trials? | • Bellera, C.; Praud, D.; Petit-Moneger, A.; McKelvie-Sebileau, P.; Soubeyran, P.; Mathoulin-Pelissier, S. Barriers to inclusion of older adults in randomised controlled clinical trials on non-Hodgkin’s lymphoma: a systematic review. Cancer Treatment Reviews 2013;39(7):812-817 • Cooper, C.; Ketley, D.; Livingston, G. Systematic review and meta-analysis to estimate potential recruitment to dementia intervention studies.International Journal of Geriatric Psychiatry 2014;29(5):515-25 • Nicholson, L. M.; Schwirian, P. M.; Groner, J. A. Recruitment and retention strategies in clinical studies with low-income and minority populations: progress from 2004 to 2014. Contemporary Clinical Trials 2015;45(Pt A):34-40 |
8. What are the best ways to predict recruitment rates to a randomised trial and what impact do such predictions have on recruitment? | • Cooper, C. L.; Hind, D.; Duncan, R.; Walters, S.; Lartey, A.; Lee, E.; Bradburn, M.A rapid review indicated higher recruitment rates in treatment trials than in prevention trials. Journal of Clinical Epidemiology 2015;68(3):347-54 |
9. What are the best approaches to optimise the informed consent process when recruiting participants to randomised trials? | • Farrell, E. H.; Phillips, K.; Morgan, B.; Savage, K.; Lewis, V.; Whistance, R. N.; Kelly, M.; Mann, M.; Blazeby, J. M.; Kinnersley, K.; Edwards, A. G. K. Audio-visual aids for informed consent for invasive healthcare procedures: A systematic review. British Journal of Surgery 2013;100:60 • Gillies, K.; Cotton, S. C.; Brehaut, J. C.; Politi, M. C.; Skea, Z. Decision aids for people considering taking part in clinical trials. Cochrane Database of Systematic Reviews 2015;11:CD009736 • Halkoaho, A.; Pietila, A. M.; Ebbesen, M.; Karki, S.; Kangasniemi, M. Cultural aspects related to informed consent in health research: A systematic review. Nursing Ethics 2015;23(6):698-712 • Eltorki, M.; Uleryk, E.; Freedman, S. B. Waiver of informed consent in pediatric resuscitation research: a systematic review. Academic Emergency Medicine 2013;20(8):822-34 • Boland, J.; Currow, D. C.; Wilcock, A.; Tieman, J.; Hussain, J. A.; Pitsillides, C.; Abernethy, A. P.; Johnson, M. J. A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: implications for palliative care research. Journal of Pain & Symptom Management 2015;49(4):762-772.e5 • Montalvo, W.; Larson, E. Participant comprehension of research for which they volunteer: a systematic review. Journal of Nursing Scholarship 2014;46(6):423-31 • Nishimura, A.; Carey, J.; Erwin, P. J.; Tilburt, J. C.; Murad, M. H.; McCormick, J. B. Improving understanding in the research informed consent process: a systematic review of 54 interventions tested in randomized control trials. BMC Medical Ethics 2013;14:28 • Treweek, S.; Lockhart, P.; Pitkethly, M.; Cook, J. A.; Kjeldstrom, M.; Johansen, M.; Taskila, T. K.; Sullivan, F. M.; Wilson, S.; Jackson, C.; Jones, R.; Mitchell, E. D. Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis. BMJ Open 2013;3(2): • Synnot, A.; Ryan, R.; Prictor, M.; Fetherstonhaugh, D.; Parker, B. Audio-visual presentation of information for informed consent for participation in clinical trials. Cochrane Database of Systematic Reviews 2014;9(5):CD003717 • Wilman, E.; Megone, C.; Oliver, S.; Duley, L.; Gyte, G.; Wright, J. M. The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the empirical research. Trials [Electronic Resource] 2015;16:502 |
10. What are the advantages and disadvantages to using technology during the recruitment process? | • No evidence available |