Continental region | South America | Western Europe | Eastern Europe | Middle East | Asia | Pacifica | Africa | ||
---|---|---|---|---|---|---|---|---|---|
Country | Brazil | Germany | Poland | Israel | Korea | China | India | Australia | South Africa |
Phase | |||||||||
0 | 0.253 (0.035–1.818) p = 0.219 | - | - | 0.547 (0.224–1.339) p = 0.180 | 0.128 (0.041–0.403) p < 0.001 | 0.567 (0.306–1.049) p = 0.067 | - | 0.080 (0.011–0.573) p = 0.001 | - |
1 | 0.330 (0.215–0.505) p < 0.001 | 0.729 (0.647–0.820) p < 0.001 | 0.127 (0.087–0.184) p < 0.001 | 0.223 (0.159–0.312) p < 0.001 | 0.656 (0.573–0.751) p < 0.001 | 0.379 (0.315–0.456) p < 0.001 | 1.517 (1.206–1.907) p < 0.001 | 0.566 (0.467–-0.686) p < 0.001 | 0.287 (0.200–0.411) p < 0.001 |
2 | 0.402 (0.280–0.577) p < 0.001 | 1.022 (0.925–1.128) p < 0.673 | 1.031 (0.896–1.185) p = 0.672 | 0.684 (0.564–0.829) p < 0.001 | 0.715 (0.633–0.808) p < 0.001 | 0.815 (0.718–0.925) p = 0.002 | 0.471 (0.335–0.662) p < 0.001 | 0.889 (0.765–-1.033) p = 0.123 | 0.807 (0.650–1.00) p = 0.050 |
3 | 1.951 (1.526–2.494) p < 0.001 | 2.336 (2.118–2.577) p < 0.001 | 3.557 (3.176–4.029) p < 0.001 | 2.798 (2.414–3.243) p < 0.001 | 1.961 (1.751–2.192) p < 0.001 | 1.596 (1.404–1.815) p < 0.001 | 1.118 (0.822–1.521) p = 0.477 | 2.968 (2.614–-3.370) p < 0.001 | 3.349 (2.840–3.950) p < 0.001 |
4 | 2.868 (2.233–3.683) p < 0.001 | 0.797 (0.675–0.942) p = 0.008 | 0.822 (0.649–1.041) p = 0.104 | 1.064 (0.829–1.365) p = 0.628 | 1.783 (1.557–2.043) p < 0.001 | 2.142 (1.865–2.458) p < 0.001 | 1.099 (0.758–1.593) p = 0.618 | 0.725 (0.562–-0.935) p = 0.013 | 1.033 (0.765–1.397) p = 0.831 |
Sponsors | |||||||||
Industry | 0.592 (0.461–0.759) p < 0.001 | 4.252 (3.800–4.760) p < 0.001 | 1.976 (1.792–2.179) p < 0.001 | 1.385 (1.222–1.570) p < 0.001 | 1.241 (1.140–1.352) p < 0.001 | 0.795 (0.716–0.884) p < 0.001 | 1.257 (1.036–1.526) p = 0.020 | 1.813 (1.638–2.006) p < 0.001 | 1.827 (1.591–2.098) p < 0.001 |
Others | 1.534 (1.278–1.842) p < 0.001 | 0.289 (0.258–0.324) p < 0.001 | 0.110 (0.082–0.147) p < 0.001 | 0.714 (0.611–0.835) p < 0.001 | 0.863 (0.785–0.950) p = 0.002 | 1.322 (1.206–1.448) p < 0.001 | 0.842 (0.674–1.052) p = 0.130 | 0.259 (0.212–-0.317) p < 0.001 | 0.230 (0.171–0.310) p < 0.001 |
Age | |||||||||
Adult | 1.679 (1.335–2.111) p < 0.001 | 0.821 (0.729–0.925) p = 0.001 | 0.379 (0.299–0.480) p < 0.001 | 0.586 (0.465–0.738) p < 0.001 | 0.968 (0.856–1.094) p = 0.617 | 1.015 (0.890–1.157) p = 0.825 | 2.695 (2.211–3.285) p < 0.001 | 0.556 (0.454–0.682) p < 0.001 | 0.585 (0.444–0.772) p < 0.001 |
Child | 0.950 (0.541–1.668) p = 0.857 | 1.001 (0.804–1.248) p = 0.989 | 1.852 (1.448–2.369) p < 0.001 | 1.546 (1.141–2.094) p = 0.005 | 0.987 (0.775–1.256) p = 0.914 | 1.011 (0.780–-1.310) p = 0.937 | 1.041 (0.604–1.794) p = 0.885 | 0.923 (0.664–1.283) p = 0.635 | 1.963 (1.418–2.718) p < 0.001 |
Senior | - | 1.778 (0.700–4.515) p = 0.220 | 1.316 (0.304–5.706) p = 0.713 | - | 1.095 (0.321–3.740) p = 0.885 | 3.518 (1.515–8.166) p = 0.006 | - | 1.366 (0.315–5.922) p = 0.676 | 1.351 (0.179–10.174) p = 0.536 |
Design | |||||||||
RCT | 1.437 (1.207–1.711) p < 0.001 | 1.253 (1.165– 1.349) p < 0.001 | 1.407 (1.273–1.556) p < 0.001 | 1.272 (1.128–1.436) p < 0.001 | 1.248 (1.152–1.351) p < 0.001 | 1.195 (1.095–1.304) p < 0.001 | 1.408 (1.180–1.681) p < 0.001 | 1.289 (1.161–1.431) p < 0.001 | 1.420 (1.235–1.633) p < 0.001 |