Clinical trial registries: more international, converging efforts are needed

Pansieri, Claudia; Pandolfini, Chiara; Bonati, Maurizio

doi:10.1186/s13063-017-1836-4

Trials

Table 2 Descriptive characteristics and quality and usability criteria applied to the 11 selected registries

From: Clinical trial registries: more international, converging efforts are needed

Name of registry	Health Canada	Weill Cornell	Yale	Mayo Clinic	HKClinical Trials	NMRR	HAS	SUKL	REec	NIHR-CRN	Mario Negri
Descriptive
Country	Canada	USA	USA	USA	Hong Kong	Malaysia	Singapore	Czech Republic	Spain	UK	Italy
Year of setup	2013	2013	N/A	N/A	2005	2007	2012	2007	N/A	N/A	N/A
Governance: funding agency	Government	N/A	N/A	N/A	University	Government	Government	Government	Government	Government	Non profit organization
Governance: managing agency	Government	Medical college/ Hospital	University	Non profit organization	University	Government	Government	Government	Government	Government	Non profit organization
The registration has some limitation?	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes
Type of study (RCT-observational-pharmacological…)	Yes	N/A	N/A	No	No	No	No	Yes	No	N/A	No
Geographic (sponsor or where conducted)	Local	Local	Local	Local	No	Local	Local	Local	Local	Local	Local
Shows total number of trials registered	No	No	Yes (281)^b	No	Yes (1845)^b	Yes (7311)^b	Yes (558)^b	No	Yes (1253)^b	Yes (15,807)^a	Yes (165)^b
Shows total number of ongoing trials registered	No	No	No	No	Yes	No	Yes	Yes	Yes	No	No
Shows total number of pediatric trials registered	No	No	No	No	No	No	No	Yes	Yes	No	No
Quality
Does the registry have a section for the results?	No	No	No	No	No	No	No	No	No	No	No
Does the registry provide trial protocol?	No	No	No	No	No	No	No	No	No	No	No
Does the registry have a distinct pediatric trials section (a flag or a therapeutic area pediatric…)?	Yes	No	No	No	No	No	No	Yes	Yes	No	No
Report the date of the last webpage update	Yes	No	No	No	No	No	Yes	Yes	No	No	No
Report the date of the last trial update	No	No	No	No	No	No	No	No	No	No	No
Clinical trial data output (RSS, XML or CVS)	No	No	No	No	No	No	No	No	No	Yes	No
Possibility to contact the registry team	Yes	Yes	Yes	No	Yes	No	Yes	No	Yes	Yes	Yes
Search tips	Yes	No	No	Yes	Yes	Yes	No	No	Yes	No	No
Usability
Multilingualism of the website	Yes	No	No	No	No	No	No	Yes	Yes	No	Yes
Multilingualism of clinical trial information	Yes	No	No	No	No	No	No	Yes	Yes	No	Yes
Simple search option	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Free text	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
List of therapeutic area or disease	No	Yes	Yes	No	No	No	Yes	Yes	No	Yes	No
Elaborate search options	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Keywords	No	No	No	No	Yes	No	No	No	No	No	Yes
Status	Yes	No	No	Yes	Yes	Yes	Yes	Yes	Yes	No	No
Study type	No	Yes	No	No	Yes	Yes	No	No	No	No	No
Intervention/drug	Yes	Yes	No	No	Yes	No	Yes	No	Yes	No	Yes
Condition/disease	Yes	No	No	No	Yes	No	No	No	Yes	No	Yes
Phase	No	Yes	No	Yes	Yes	No	Yes	No	Yes	No	No
Age	Yes	No	Yes	Yes	No	No	No	Yes	Yes	No	No
Gender	Yes	No	Yes	Yes	No	No	No	Yes	Yes	No	No
Location	No	No	No	Yes	No	No	Yes	Yes	Yes	No	No
Sponsor	Yes	No	No	No	Yes	Yes	Yes	No	Yes	No	No

^aNumber may exceed total number of trials in the registry because some trials may be represented in more than one category. This numbers refers to the total number of trials registered before July 2015
^bThe total number of trials registered and rechecked was updated in September 2016: Yale - 459; HKClinical trials - 1999; NMRR - 8890; HAS - 574; REec - 2568;
Mario Negri - 178
URLs: Health Canada: http://ctdb-bdec.hc-sc.gc.ca/ctdb-bdec/index-eng.jsp; Weill Cornell: http://jcto.weill.cornell.edu/; Yale: http://www.yalestudies.org/; Mayo Clinic: http://www.mayo.edu/research/clinical-trials; HKClinicalTrials: http://www.hkclinicaltrials.com/; NMRR: https://www.nmrr.gov.my/fwbLoginPage.jsp; HAS: http://www.hsa.gov.sg/content/hsa/en/Health_Products_Regulation/Clinical_Trials/Overview/Clinical_Trials_Register.html; SUKL: http://www.sukl.eu/modules/evaluation/; REec: https://reec.aemps.es/reec/public/web.html; NIHR-CRN: http://public.ukcrn.org.uk/search/ "The NIHR-CRN is no longer active and users can visit the UK Clinical Trials Gateway (https://www.ukctg.nihr.ac.uk/) to search for trials."; Mario Negri: http://registro.marionegri.it/frontend/index.php

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ISSN: 1745-6215

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