Inclusion | Exclusion |
---|---|
≥18 years Diagnosis of moderate to severe plaque psoriasis (PASI ≥8) Adalimumab naïve Candidate for biologic therapy Willing and able to use adequate contraceptives during the study | History of significant MTX toxicity, intolerability, or contraindication Known liver or kidney malfunction Alcohol abuse Bone marrow hypoplasia, leukocytopenia, thrombocytopenia, or significant anemia Known severe or chronic infections like tuberculosis or HIV Ulcers in the oral cavity or known active ulcers in digestive tract Pregnant or nursing women Need for live vaccinations Use of other immunosuppressive medication (e.g., prednisone, mycophenolate mofetil (Cellcept), cyclosporine (Neoral), sirolimus (Rapamune), systemic tacrolimus (Prograf)) |