Table 1 Doses of baclofen or placebo adjusted on daily assessment of the patient’s creatinine clearance
MDRD | D1 Loading dose | D2 and following days until extubation/tracheotomy at D15 |
|---|---|---|
Cl ≥90 | 150 mg | 50-50-50 |
Cl 89–60 | 100 mg | 30-20-50 |
Cl 30–59 | 70 mg | 20-20-30 |
Cl <30 or continuous HD | 50 mg | 20-10-20 |
IHD | 50 mg | 50 mg before each session |
Cl <15 without HD/IHD | 50 mg | No administration |