Fig. 1From: Improving treatment and liver fibrosis outcomes with metformin in HCV-HIV co-infected and HCV mono-infected patients with insulin resistance: study protocol for a randomized controlled trialFlow diagram of study processes. Sixty participants meeting eligibility criteria will be randomized in a 1:1 ratio using variable block sizes to either arm 1, metformin 2Â g (1Â g BID) plus lifestyle (Metformin group), or to arm 2, lifestyle alone (Control group). Abbreviations: HCV hepatitis, HIV human immunodeficiency virus, IR insulin resistance, BID twice daily, DAA direct-acting antiviral therapy, kPa kilopascalsBack to article page