Type of outcomes | Specific outcomes | Measurements | ||
---|---|---|---|---|
1-baseline (week 0) | 2-moment (week 4) | 3-moment (week 12) | ||
Primary outcomes | Endothelial function as measured by flow-mediated vasodilatation | X | Â | X |
Secondary outcomes | Vascular function: heart rate variability, aortic pulse wave velocity, augmentation index and blood pressure | X | Â | X |
Morphological component: weight, height, BMI, waist circumference | X | X | Â | |
 | Body composition: fat mass and non-bone lean body mass | X |  | X |
 | Body temperature | X |  | X |
 | Plasma samples and biochemical analysis: LDL cholesterol (LDL-c), HDL cholesterol (HDL-c), total cholesterol, triglycerides, glucose, glycated haemoglobin (HbA1c) | X |  | X |
 | Fitness component: self-reported fitness, 1RM, hand-grip and peak uptake of volume of oxygen | X |  | X |
 | Self-perceived health: health-related quality of life | X |  | X |
 | Recent Physical Activity Questionnaire | X | X | X |
 | Demographic information | X |  |  |
 | Side effects | X | X | X |