Baseline information | Patient characteristics (age, sex, comorbities) |
Inclusion criteria and consent details | |
Date and time of hospital admission | |
Date and time of admission to intensive care unit | |
APACHE II and III score on admission and immunocompromised status | |
Date and time of randomization | |
Cardiac arrest characteristics | Location (in or out of- hospital), date and time of cardiac arrest |
Bystander cardiopulmonary resuscitation | |
Time (minutes) until emergency responder arrival | |
Initial cardiac rhythm | |
Time of first defibrillation and number of defibrillation episodes | |
Time of return of spontaneous circulation | |
Total adrenaline dose | |
Suspected cause of cardiac arrest (arrhythmic, hypoxic, ischaemic, pulseless electrical activity) | |
Intensive care unit procedures and ventilation management | Time of first arterial blood gas measurement and number of arterial blood gas measurements in first 24 h |
Therapeutic hypothermia initiated (yes or no) | |
Nutrition commenced (yes or no) | |
Coronary angiography in first 24 h | |
Bicarbonate infusion commenced in first 24 h | |
Recurrent cardiac arrhythmia (yes or no) | |
Need for extracorporeal membrane oxygenation or renal replacement therapy | |
Electroencephalography, computed tomography of the brain or echocardiography (yes and finding or not performed) in first 24 h | |
Intravenous medication use (fentanyl, midazolam, neuromuscular blockage medication, midazolam, morphine, propofol) | |
Duration of mechanical ventilation | |
Arterial blood gas data during first 36 h of intensive care unit care while mechanically ventilated | |
Ventilation data during first 36 h of intensive care unit care while mechanically ventilated | |
Urinary and serum creatinine concentrations while in the intensive care unit | |
Clinical outcomes | Date, time and vital status at discharge from intensive care unit |
Date, time and vital status at discharge from hospital | |
Destination after discharge from hospital | |
Feasibility measures | Screened:recruited patient ratio and weekly recruitment rate |
Separation in PaCO2 levels between groups | |
Time (minutes) from cardiac arrest to first arterial blood gas analysis in intensive care unit | |
Safety measures | Occurrence of severe raised intracranial pressure or right ventricular failure, incidence of acute kidney injury as estimated using RIFLE (‘risk, injury, failure, loss, end-stage’ renal disease) criteria and liver failure |
Neurological evaluation measure | Glasgow Outcome Scale (Extended) evaluation performed at 6 months |