Table 2 Summary of the trial results currently reported
From: Biventricular pacing in heart failure: update on results from clinical trials
Trial | Number of patients | Randomised comparison | Increase in 6 min walk | Increase in VO2 max/ejection fraction | Improved quality of life | Decreased hospital admissions |
|---|---|---|---|---|---|---|
Bordeaux series [13] | 47 | No | Not done | No significant change | Functional class improvement | Not stated |
InSync [12] | 103 | No | 50 m (P = 0.01) | Not stated | 45% | Not done |
PATH-CHF [30] | 42 | Yes | 60 m | VO2 max increased 23% | Increased | Not stated |
MUSTIC (SR) [14] | 58 | Yes | 23% (P < 0.001) | 8% (P < 0.03) | 32% (P < 0.001) | 3 admitted during biventricular pacing versus 9 during no pacing |
MIRACLE [15] | 370 | Yes (patients and physicians) | 35 m (P = 0.04) | Awaited | Small but significant (P < 0.002) | 233 days (biventricular) versus 621 days (control) over 6 months |
CONTAC CD | 460 (33% NYHA class II) | Yes | No significant change | VO2 max 9% increase; LV diameter 4 mm decrease (P = 0.001) | No significant change | Not stated |